Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0059 | 0.0241 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0059 | 0.0241 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0059 | 0.0241 | 0.1034 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | nuclear receptor NHR-88 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0059 | 0.0241 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0059 | 0.0241 | 0.1034 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0059 | 0.0241 | 0.1034 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | nuclear hormone receptor | 0.0059 | 0.0241 | 0.1034 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | nuclear hormone receptor | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0059 | 0.0241 | 0.0241 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0181 | 0.1908 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0772 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0059 | 0.0241 | 0.1034 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.026 | 0.026 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.026 | 0.026 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.026 | 0.026 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0059 | 0.0241 | 0.0241 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0212 | 0.2332 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.026 | 0.026 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | thyroid hormone receptor | 0.0059 | 0.0241 | 0.1034 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | coup transcription factor | 0.0059 | 0.0241 | 0.1034 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0059 | 0.0241 | 0.1034 |
Brugia malayi | steroid hormone receptor | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0059 | 0.0241 | 0.1034 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0059 | 0.0241 | 0.0241 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0241 | 0.0241 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0212 | 0.2332 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.