Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2c (5-HT2c) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0342 | 0.1808 | 0.1685 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.1189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0847 | 0.6691 | 0.6532 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0938 | 0.7566 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0342 | 0.1808 | 0.1685 |
Brugia malayi | cytochrome P450 | 0.0342 | 0.1808 | 0.1413 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0342 | 0.1808 | 0.1685 |
Mycobacterium leprae | putative cytochrome p450 | 0.0342 | 0.1808 | 0.6407 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0358 | 0.1961 | 0.184 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0451 | 0.286 | 0.1827 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0451 | 0.286 | 0.3378 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0203 | 0.0459 | 0.5 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0358 | 0.1961 | 0.184 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0342 | 0.1808 | 0.1685 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0451 | 0.286 | 0.1284 |
Brugia malayi | Cytochrome P450 family protein | 0.0342 | 0.1808 | 0.1413 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0342 | 0.1808 | 0.6407 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0342 | 0.1808 | 0.1685 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0938 | 0.7566 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0342 | 0.1808 | 0.1685 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0938 | 0.7566 | 0.7029 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0342 | 0.1808 | 0.1897 |
Trypanosoma brucei | cytochrome P450, putative | 0.1189 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0203 | 0.0459 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0561 | 0.3927 | 0.3635 |
Brugia malayi | Cytochrome P450 family protein | 0.0342 | 0.1808 | 0.1413 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.1189 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.1189 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0451 | 0.286 | 0.3378 |
Giardia lamblia | DNA topoisomerase II | 0.0189 | 0.0322 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0447 | 0.2821 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0342 | 0.1808 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0451 | 0.286 | 0.2419 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.1189 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0358 | 0.1961 | 0.184 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0342 | 0.1808 | 0.1685 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0938 | 0.7566 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0358 | 0.1961 | 0.184 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0938 | 0.7566 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.1189 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0938 | 0.7566 | 1 |
Leishmania major | cytochrome p450-like protein | 0.1189 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0261 | 0.1019 | 0.0788 |
Brugia malayi | Cytochrome P450 family protein | 0.1189 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0342 | 0.1808 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0203 | 0.0459 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0342 | 0.1808 | 0.1413 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0203 | 0.0459 | 0.5 |
Echinococcus multilocularis | 0.0342 | 0.1808 | 1 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.1189 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0342 | 0.1808 | 0.1413 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0938 | 0.7566 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0203 | 0.0459 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0938 | 0.7566 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0342 | 0.1808 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 37 nM | Displacement of [3H]-ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptor | ChEMBL. | 10956215 |
Ki (binding) | = 37 nM | Displacement of [3H]-ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptor | ChEMBL. | 10956215 |
Ki (binding) | = 76 nM | Displacement of [3H]-mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptor | ChEMBL. | 10956215 |
Ki (binding) | = 76 nM | Displacement of [3H]-mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptor | ChEMBL. | 10956215 |
Selectivity (binding) | = 2 | Relative affinities for rat 5-HT2C receptors and 5-HT2A receptors | ChEMBL. | 10956215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.