Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0976 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0296 | 0.0296 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1153 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1153 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0668 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0296 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1153 | 0.1271 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1153 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7043 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0473 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.068 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0846 | 0.0846 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0296 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5805 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.