Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1468 | 0.1468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0401 | 0.0401 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0401 | 0.1265 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0401 | 0.0401 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2387 | 0.2387 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1468 | 0.1468 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0401 | 0.1265 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2387 | 0.2387 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0401 | 0.0401 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2387 | 0.2387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3173 | 0.3173 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3173 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0401 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2387 | 0.2387 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1468 | 0.4626 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.