Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | perilipin 1 | Starlite/ChEMBL | No references |
Homo sapiens | hepatocyte nuclear factor 4, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Transcription factor HNF-4 homolog, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Hepatocyte nuclear factor 4-beta, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0174 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0174 | 0.019 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0174 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0174 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0174 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0174 | 0.5 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0174 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0152 | 0.9162 | 0.9162 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0152 | 0.9162 | 0.9162 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0174 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.014 | 0.8329 | 0.8329 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0152 | 0.9162 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0174 | 0.019 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0022 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0174 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0152 | 0.9162 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 1.406 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 1.475 uM | PubChem BioAssay. Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 33.5875 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.