Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 163 aa | 133 aa | 27.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0039 | 0.1236 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.234 | 0.3289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3205 | 0.3096 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.133 | 0.1767 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2077 | 0.2892 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0384 | 0.0229 |
Echinococcus granulosus | expressed protein | 0.004 | 0.1287 | 0.1147 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0384 | 0.0229 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0384 | 0.3103 |
Trichomonas vaginalis | rotamase, putative | 0.004 | 0.1287 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2077 | 0.195 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3205 | 0.3096 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2077 | 0.195 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0384 | 0.5 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0039 | 0.1236 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0384 | 0.034 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3205 | 0.3096 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0384 | 0.0229 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0384 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.133 | 0.1767 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0384 | 0.0229 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2077 | 0.2892 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0384 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.1236 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.133 | 0.1191 |
Trichomonas vaginalis | rotamase, putative | 0.0039 | 0.1236 | 0.9442 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2077 | 0.195 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3205 | 0.3096 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0384 | 0.0229 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2077 | 0.195 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3205 | 0.4591 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3205 | 0.3096 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3205 | 0.4591 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0384 | 0.0229 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0384 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0039 | 0.1236 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0384 | 0.0229 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.1287 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.004 | 0.1287 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0384 | 0.034 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6794 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0384 | 0.034 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2077 | 0.195 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2077 | 0.195 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0384 | 0.3103 |
Schistosoma mansoni | rotamase | 0.004 | 0.1287 | 0.1147 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.1236 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.234 | 0.3289 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.004 | 0.1287 | 0.1701 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0384 | 0.0229 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3205 | 0.4591 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0384 | 0.3103 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0384 | 0.3103 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3205 | 0.4591 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.234 | 0.3289 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0384 | 0.034 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3205 | 0.3096 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.1236 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0384 | 0.3103 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0384 | 0.0229 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2077 | 0.195 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0384 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3205 | 0.3096 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3205 | 0.4591 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3205 | 0.4591 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6794 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6794 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.234 | 0.3289 |
Echinococcus multilocularis | expressed protein | 0.004 | 0.1287 | 0.1147 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0384 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 27.2824 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.2212 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 78.9077 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.