Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0222 | 0.0389 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0142 | 0.1873 | 0.1873 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0222 | 0.0222 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0142 | 0.1873 | 0.1873 |
Schistosoma mansoni | microtubule-associated protein tau | 0.06 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0222 | 0.0222 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0222 | 0.0389 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0222 | 0.0222 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0222 | 0.0222 |
Schistosoma mansoni | alpha-glucosidase | 0.0122 | 0.1523 | 0.1523 |
Schistosoma mansoni | alpha-glucosidase | 0.0122 | 0.1523 | 0.1523 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0222 | 0.0222 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0142 | 0.1873 | 0.328 |
Brugia malayi | hypothetical protein | 0.0151 | 0.2043 | 0.3577 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.5711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.2043 | 0.3577 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0142 | 0.1873 | 0.1873 |
Onchocerca volvulus | 0.0151 | 0.2043 | 0.3577 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0142 | 0.1873 | 0.328 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0291 | 0.4517 | 0.791 |
Brugia malayi | Pax transcription factor protein 2 | 0.0291 | 0.4517 | 0.791 |
Onchocerca volvulus | 0.0291 | 0.4517 | 0.791 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0358 | 0.5711 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.3443 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.06 | 1 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0358 | 0.5711 | 1 |
Onchocerca volvulus | 0.0082 | 0.0814 | 0.1425 | |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.