Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.726 | 0.726 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.4732 | 0.4732 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.726 | 0.726 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.726 | 0.726 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.726 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.4593 | 0.4593 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.4732 | 0.4732 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 0.4732 | 0.4732 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.4732 | 0.4732 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.726 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.4732 | 0.4732 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0816 | 0.0816 |
Echinococcus multilocularis | musashi | 0.0028 | 0.4732 | 0.4732 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.726 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 1 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0816 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0678 | 0.0678 |
Onchocerca volvulus | 0.0028 | 0.4732 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0678 | 0.0678 |
Brugia malayi | hypothetical protein | 0.0037 | 0.726 | 0.726 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.1218 | 0.1218 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.726 | 0.726 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.4732 | 0.4732 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.726 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1218 | 0.1218 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.4732 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0816 | 0.0816 |
Echinococcus granulosus | lamin | 0.0028 | 0.4732 | 0.4732 |
Schistosoma mansoni | lamin | 0.0028 | 0.4732 | 0.4732 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.4732 | 0.4732 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.4732 | 0.4732 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.