Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4666 | 0.4666 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4666 | 0.4666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4666 | 0.4666 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4666 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4666 | 0.4666 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4666 | 0.4666 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.5371 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4666 | 0.4666 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.5371 | 0.5371 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4666 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5371 | 0.5371 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.