Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.1152 | 0.2086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.1152 | 0.2229 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.1152 | 0.2086 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.1152 | 0.2086 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0322 | 0.0239 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.1152 | 0.2229 |
Onchocerca volvulus | 0.0028 | 0.4393 | 1 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0531 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1152 | 0.2086 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0322 | 0.0215 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.1152 | 0.2086 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.1152 | 0.1054 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.1719 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.1152 | 0.1054 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1152 | 0.2086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.0222 | 0.0114 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0222 | 0.0114 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.0925 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4393 | 0.4331 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0222 | 0.0114 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1152 | 0.2086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0322 | 0.0239 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1672 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.1152 | 0.2229 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.1152 | 0.2229 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1609 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.0222 | 0.0114 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1152 | 0.1054 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.1152 | 0.2229 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1152 | 0.2229 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.1152 | 0.2086 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.1152 | 0.2086 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.4678 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4393 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1152 | 0.2086 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 1 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.1152 | 0.2229 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.4678 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.1152 | 0.2086 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.0925 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.1152 | 0.2086 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.1152 | 0.2229 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.1152 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.1152 | 0.1054 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.0222 | 0.0114 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4393 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.1152 | 0.2229 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0925 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.1152 | 0.2229 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0925 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0322 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.1152 | 0.2229 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0322 | 0.0223 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4678 | 0.4619 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.0222 | 0.0114 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8867 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.1152 | 0.2086 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.1152 | 0.2229 |
Onchocerca volvulus | 0.001 | 0.1152 | 0.2229 | |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.1152 | 0.2229 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1609 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.1152 | 0.1054 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.1152 | 0.2086 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0322 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0322 | 0.0239 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4678 | 0.4619 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0322 | 0.0223 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1152 | 0.2229 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1152 | 0.2229 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.1152 | 0.2086 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.1152 | 0.1054 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.1152 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0322 | 0.0239 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.1152 | 0.1054 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0222 | 0.0114 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.1152 | 0.1054 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0222 | 0.0114 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.1152 | 0.2086 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.1152 | 0.2229 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.1152 | 0.1054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.