Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | abhydrolase domain containing 10 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | hydrolase, alpha/beta fold family, putative | abhydrolase domain containing 10 | 292 aa | 247 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable reductase | 0.0234 | 0.6892 | 0.8837 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0103 | 0.2555 | 0.401 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0261 | 0.7757 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0261 | 0.7757 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0234 | 0.6892 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0036 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0103 | 0.2535 | 0.2985 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0261 | 0.7757 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0036 | 0.0313 | 0.0801 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0036 | 0.0313 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0036 | 0.0313 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5905 | 0.5773 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0234 | 0.6892 | 0.8837 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3905 | 1 |
Treponema pallidum | NADH oxidase | 0.0036 | 0.0313 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0036 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0234 | 0.6892 | 0.8837 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3905 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0103 | 0.2535 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0234 | 0.6892 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0103 | 0.2555 | 0.401 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0036 | 0.0313 | 0.5 |
Brugia malayi | glutathione reductase | 0.0103 | 0.2535 | 0.6493 |
Trypanosoma brucei | trypanothione reductase | 0.0103 | 0.2535 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5905 | 0.5773 |
Echinococcus multilocularis | geminin | 0.0205 | 0.5905 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0036 | 0.0313 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0103 | 0.2535 | 1 |
Leishmania major | trypanothione reductase | 0.0103 | 0.2535 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3905 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0261 | 0.7757 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0103 | 0.2535 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0103 | 0.2535 | 0.6493 |
Plasmodium vivax | glutathione reductase, putative | 0.0103 | 0.2535 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0036 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0234 | 0.6892 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0036 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0103 | 0.2535 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0036 | 0.0313 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.5905 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0103 | 0.2535 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0.103 uM | PubChem BioAssay. Late stage assay provider results from the probe development effort to identify inhibitors of PME-1: fluorescence-based dose response biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) inhibition of ABHD10 Set 1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.