TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 569.732 | Formula: C32H47N3O6
H donors: 1 H acceptors: 2 LogP: 4.56 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@@H](N1C[C@@H](C)[C@H](OCCCC[C@@H](Oc2c(C1=O)cc(cc2)N(C)C)C)CN(Cc1ccc2c(c1)OCO2)C)C
InChi: 1S/C32H47N3O6/c1-22-17-35(23(2)20-36)32(37)27-16-26(33(4)5)11-13-28(27)41-24(3)9-7-8-14-38-31(22)19-34(6)18-25-10-12-29-30(15-25)40-21-39-29/h10-13,15-16,22-24,31,36H,7-9,14,17-21H2,1-6H3/t22-,23+,24+,31-/m1/s1
InChiKey: WIYHORLWMFSPCL-ZJKUCEDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Trypanosoma brucei	hypothetical protein, conserved	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	HpcH/HpaI aldolase/citrate lyase family, putative	Get druggable targets OG5_146801	All targets in OG5_146801
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Leishmania donovani	HpcH/HpaI aldolase/citrate lyase family, putative	Get druggable targets OG5_146801	All targets in OG5_146801
Trypanosoma brucei	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_146801	All targets in OG5_146801

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0031	0.0031
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0137	0.233	0.3015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0343	0.0314
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0161	0.292	0.2704
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0464	0.0464
Trypanosoma brucei	hypothetical protein, conserved	0.0257	0.526	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0234	0.4709	0.4693
Mycobacterium ulcerans	glutaminase	0.033	0.7045	0.5
Loa Loa (eye worm)	hypothetical protein	0.0451	1	1
Loa Loa (eye worm)	hypothetical protein	0.0234	0.4709	0.4709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Onchocerca volvulus	Cathepsin F homolog	0.0234	0.4709	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0127	0.2085	0.2085
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0786	0.0505
Brugia malayi	Cathepsin L-like precursor	0.0161	0.292	0.292
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0296	0.0296
Schistosoma mansoni	voltage-gated potassium channel	0.016	0.2893	0.2893
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0053	0.0296	0.0296
Echinococcus granulosus	cathepsin l1	0.0161	0.292	0.2898
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0464	0.0464
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0234	0.4709	0.4693
Giardia lamblia	Cathepsin B precursor	0.0176	0.3297	1
Echinococcus granulosus	cathepsin b	0.0451	1	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0296	0.0296
Giardia lamblia	Cathepsin B precursor	0.0176	0.3297	1
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Echinococcus multilocularis	cathepsin b	0.0451	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0296	0.0296
Brugia malayi	cathepsin L-like cysteine proteinase	0.0053	0.0296	0.0296
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0146	0.2565	0.2542
Brugia malayi	Cathepsin L-like precursor	0.0234	0.4709	0.4709
Echinococcus multilocularis	cathepsin L	0.0053	0.0296	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0161	0.292	0.292
Plasmodium vivax	vivapain-2	0.0234	0.4709	1
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0296	0.0296
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.2085	0.2085
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.2085	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0234	0.4709	0.4548
Schistosoma mansoni	cathepsin s	0.0073	0.0786	0.0786
Onchocerca volvulus		0.0234	0.4709	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Echinococcus granulosus	cathepsin b	0.0451	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.2085	0.4054
Toxoplasma gondii	cathepsin CPL	0.0234	0.4709	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0137	0.233	0.3015
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0234	0.4709	1
Schistosoma mansoni	glutaminase	0.033	0.7045	0.7045
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0234	0.4709	0.4693
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0343	0.0343
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0343	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0786	0.0786
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0053	0.0296	0.0296
Echinococcus multilocularis	cathepsin L	0.0127	0.2085	0.2061
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0053	0.0296	0.0296
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0343	0.0343
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0343	0.0343
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0296	0.0296
Echinococcus multilocularis	cathepsin b	0.0451	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0296	0.0296
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0053	0.0296	0.0296
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0343	0.0314
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0073	0.0786	0.0786
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.526	0.5115
Brugia malayi	Cathepsin L-like precursor	0.0234	0.4709	0.4709
Echinococcus multilocularis	cysteine protease	0.0234	0.4709	0.4693
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0234	0.4709	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0127	0.2085	0.1844
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.292	0.5946
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0786	0.0505
Onchocerca volvulus		0.0234	0.4709	1
Brugia malayi	Cathepsin L-like precursor	0.0234	0.4709	0.4709
Trypanosoma cruzi	cysteine peptidase, putative	0.0234	0.4709	0.4548
Giardia lamblia	Cathepsin B precursor	0.0176	0.3297	1
Trypanosoma cruzi	cysteine protease, putative	0.0127	0.2085	0.1844
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.2085	0.4054
Trypanosoma cruzi	hypothetical protein, conserved	0.0257	0.526	0.5115
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Loa Loa (eye worm)	hypothetical protein	0.0161	0.292	0.292
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0127	0.2085	0.2085
Plasmodium vivax	unspecified product	0.0073	0.0786	0.1111
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0296	0.0296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Trypanosoma cruzi	cysteine proteinase, putative	0.0127	0.2085	0.1844
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Entamoeba histolytica	cysteine proteinase 2	0.0127	0.2085	0.4054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0343	0.0343
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0296	0.0296
Trypanosoma cruzi	cysteine proteinase, putative	0.0127	0.2085	0.1844
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0296	0.0296
Schistosoma mansoni	cathepsin F (C01 family)	0.0234	0.4709	0.4709
Loa Loa (eye worm)	ctsf protein	0.0234	0.4709	0.4709
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0234	0.4709	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0161	0.292	0.292
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0296	0.0296
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0296	0.0296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0234	0.4709	1
Trichomonas vaginalis	glutaminase, putative	0.033	0.7045	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	0.3297	0.3093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0176	0.3297	0.4447
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0296	0.0296
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0296	0.0296
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Toxoplasma gondii	cathepsin B	0.0176	0.3297	0.68
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0343	0.0343
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Plasmodium vivax	vivapain-1	0.0127	0.2085	0.4054
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0031	0.0031
Loa Loa (eye worm)	cathepsin B	0.0176	0.3297	0.3297
Entamoeba histolytica	cysteine proteinase, putative	0.0234	0.4709	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0343	0.0314
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0296	0.0296
Brugia malayi	cathepsin F-like cysteine proteinase	0.0053	0.0296	0.0296
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0146	0.2565	0.2565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Onchocerca volvulus		0.0234	0.4709	1
Onchocerca volvulus		0.0161	0.292	0.5946
Onchocerca volvulus		0.0234	0.4709	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0042	0.0031	0.0031
Echinococcus granulosus	cysteine protease	0.0127	0.2085	0.2061
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Brugia malayi	fibroinase precursor	0.0053	0.0296	0.0296
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0451	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0146	0.2565	0.2565
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0296	0.0296
Loa Loa (eye worm)	cysteine protease	0.0234	0.4709	0.4709
Onchocerca volvulus		0.0234	0.4709	1
Entamoeba histolytica	cysteine proteinase, putative	0.0234	0.4709	1
Entamoeba histolytica	cysteine protease, putative	0.0234	0.4709	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0234	0.4709	0.4709
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0176	0.3297	0.3818
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Schistosoma mansoni	cathepsin S (C01 family)	0.0053	0.0296	0.0296
Brugia malayi	Cathepsin L-like precursor	0.0234	0.4709	0.4709
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0161	0.292	0.292
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Echinococcus granulosus	cathepsin l1	0.0234	0.4709	0.4693
Echinococcus granulosus	cathepsin L	0.0053	0.0296	0.0266
Brugia malayi	Cathepsin L-like precursor	0.0073	0.0786	0.0786
Brugia malayi	glutaminase DH11.1	0.033	0.7045	0.7045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3297	0.3297
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.2085	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0127	0.2085	0.2085
Brugia malayi	Papain family cysteine protease containing protein	0.0234	0.4709	0.4709
Leishmania major	hypothetical protein, conserved	0.0257	0.526	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0234	0.4709	0.4693
Brugia malayi	cathepsin L precursor	0.0053	0.0296	0.0296
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0127	0.2085	0.4054
Schistosoma mansoni	voltage-gated potassium channel	0.016	0.2893	0.2893
Trypanosoma cruzi	cysteine peptidase, putative	0.0234	0.4709	0.4548
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0234	0.4709	0.654
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654
Plasmodium vivax	vivapain-3	0.0127	0.2085	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.0234	0.4709	0.7196
Loa Loa (eye worm)	hypothetical protein	0.006	0.0464	0.0464
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0053	0.0296	0.0296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.2085	0.2085
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.292	0.3889
Loa Loa (eye worm)	hypothetical protein	0.0127	0.2094	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0786	0.0786
Loa Loa (eye worm)	glutaminase 2	0.033	0.7045	0.7045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.2085	0.2651
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.0296	0.0296
Loa Loa (eye worm)	fibroinase	0.0234	0.4709	0.4709
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0786	0.0786
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Entamoeba histolytica	cysteine proteinase 1, putative	0.0127	0.2085	0.4054
Onchocerca volvulus		0.0234	0.4709	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.292	0.3889
Plasmodium vivax	vivapain-2	0.0234	0.4709	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0451	1	1
Plasmodium vivax	unspecified product	0.0127	0.2085	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0234	0.4709	1
Onchocerca volvulus		0.0234	0.4709	1
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0451	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0073	0.0786	0.0786
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0073	0.0786	0.0786
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.2085	0.1844
Schistosoma mansoni	cathepsin C	0.0053	0.0296	0.0296
Echinococcus granulosus	cathepsin L cysteine protease	0.0127	0.2085	0.2061
Loa Loa (eye worm)	glutaminase	0.033	0.7045	0.7045
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Brugia malayi	Cathepsin L-like precursor	0.0234	0.4709	0.4709
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.2085	0.2651
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0053	0.0296	0.0296
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0464	0.0464
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0146	0.2565	0.2542
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0234	0.4709	0.4693
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0234	0.4709	0.4709
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0234	0.4709	0.4548
Entamoeba histolytica	cysteine protease, putative	0.0127	0.2085	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0234	0.4709	0.654
Schistosoma mansoni	cathepsin F (C01 family)	0.0234	0.4709	0.4709
Leishmania major	cathepsin L-like protease	0.0234	0.4709	0.7196
Brugia malayi	cathepsin L-like precursor	0.0161	0.292	0.292
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0053	0.0296	0.0296
Echinococcus multilocularis	cysteine protease	0.0234	0.4709	0.4693
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0234	0.4709	0.4693
Loa Loa (eye worm)	hypothetical protein	0.0161	0.292	0.292
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0234	0.4709	0.8266
Echinococcus granulosus	cathepsin L	0.0127	0.2085	0.2061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0234	0.4709	0.654
Trypanosoma cruzi	cruzipain precursor, putative	0.0234	0.4709	0.4548
Brugia malayi	Cathepsin L-like precursor	0.0161	0.292	0.292
Brugia malayi	Cathepsin L-like precursor	0.0234	0.4709	0.4709
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0234	0.4709	0.654

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2132273

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1710623