Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H2 | Starlite/ChEMBL | References |
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma japonicum | Alpha-1D adrenergic receptor, putative | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Schistosoma mansoni | amine GPCR | Get druggable targets OG5_128924 | All targets in OG5_128924 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | biogenic amine 5HT receptor | Histamine H3 receptor | 445 aa | 405 aa | 25.2 % |
Brugia malayi | hypothetical protein | histamine receptor H2 | 397 aa | 333 aa | 23.1 % |
Loa Loa (eye worm) | hypothetical protein | Histamine H3 receptor | 445 aa | 384 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.1874 | 0.8772 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0346 | 0.0721 | 0.0542 |
Brugia malayi | hypothetical protein | 0.0891 | 0.3597 | 0.3155 |
Echinococcus granulosus | thymidylate synthase | 0.1874 | 0.8772 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1874 | 0.8772 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2107 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0439 | 0.1211 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0891 | 0.3597 | 1 |
Brugia malayi | thymidylate synthase | 0.1874 | 0.8772 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0245 | 0.0189 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1874 | 0.8772 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0346 | 0.0721 | 0.0542 |
Loa Loa (eye worm) | thymidylate synthase | 0.1874 | 0.8772 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2107 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0891 | 0.3597 | 0.3473 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2107 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0439 | 0.1211 | 0.1381 |
Echinococcus multilocularis | thymidylate synthase | 0.1874 | 0.8772 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2107 | 1 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0891 | 0.3597 | 0.3155 |
Giardia lamblia | Thymidine kinase | 0.0245 | 0.0189 | 0.5 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0346 | 0.0721 | 0.0542 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2107 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1874 | 0.8772 | 1 |
Onchocerca volvulus | 0.1874 | 0.8772 | 0.5 | |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0346 | 0.0721 | 0.0542 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2.8 nM | Binding affinity against rat histamine H3 receptor | ChEMBL. | 12372500 |
Ki (binding) | = 2.8 nM | Binding affinity against rat histamine H3 receptor | ChEMBL. | 12372500 |
Ki (binding) | = 900 nM | Binding affinity to the human Histamine H2 receptor | ChEMBL. | 12372500 |
Ki (binding) | = 900 nM | Binding affinity to the human Histamine H2 receptor | ChEMBL. | 12372500 |
Ki (binding) | = 8900 nM | Binding affinity to the human Histamine H1 receptor | ChEMBL. | 12372500 |
Ki (binding) | = 8900 nM | Binding affinity to the human Histamine H1 receptor | ChEMBL. | 12372500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.