Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7163 | 0.7163 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0005 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0005 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3848 | 0.3848 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0.0005 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0005 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7163 | 0.7163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7163 | 0.7163 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7163 | 0.7163 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3848 | 0.3848 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3848 | 0.3848 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0005 | 0.0005 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0.0005 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0005 | 0.0005 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0.0005 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.