Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0826 | 0.3989 | 0.3989 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0826 | 0.3989 | 0.3989 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0942 | 0.4576 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0942 | 0.4576 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2007 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0826 | 0.3989 | 0.8717 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0826 | 0.3989 | 0.3989 |
Loa Loa (eye worm) | hypothetical protein | 0.2007 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2007 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2007 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2007 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0826 | 0.3989 | 0.3989 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2007 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0826 | 0.3989 | 0.3989 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0826 | 0.3989 | 0.3989 |
Echinococcus multilocularis | protein patched | 0.0826 | 0.3989 | 0.3989 |
Entamoeba histolytica | cyclin, putative | 0.0043 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2007 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0826 | 0.3989 | 0.3989 |
Plasmodium falciparum | cyclin | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2007 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0043 | 0 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0826 | 0.3989 | 0.3989 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.3989 | 0.3989 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0826 | 0.3989 | 0.3989 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0942 | 0.4576 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0942 | 0.4576 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2007 | 1 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0826 | 0.3989 | 0.3989 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.6 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK2/E) | ChEMBL. | 11354366 |
IC50 (binding) | = 0.6 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK2/E) | ChEMBL. | 11354366 |
IC50 (binding) | > 2.1 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK4/D1) | ChEMBL. | 11354366 |
IC50 (binding) | > 2.1 uM | In vitro inhibitory activity against human cyclin dependent kinase (CDK4/D1) | ChEMBL. | 11354366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.