Detailed information for compound 1710959

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.565 | Formula: C24H35N5O5
  • H donors: 1 H acceptors: 4 LogP: 0.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](N1C[C@@H](C)[C@@H](OCc2n(CCCC1=O)nnc2)CN(Cc1ccc2c(c1)OCO2)C)C
  • InChi: 1S/C24H35N5O5/c1-17-11-28(18(2)14-30)24(31)5-4-8-29-20(10-25-26-29)15-32-23(17)13-27(3)12-19-6-7-21-22(9-19)34-16-33-21/h6-7,9-10,17-18,23,30H,4-5,8,11-16H2,1-3H3/t17-,18-,23+/m1/s1
  • InChiKey: GOEWTOAFXZXQCM-PNCHPQGNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0019 0.0005 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0117 0.0627 0.0603
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.0297 0.029
Loa Loa (eye worm) Smad1 0.0026 0.0045 0.004
Onchocerca volvulus 0.024 0.1415 0.1411
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.1585 1 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0007 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0627 0.062
Loa Loa (eye worm) hypothetical protein 0.012 0.0648 0.0643
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0025 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Echinococcus multilocularis beta LACTamase domain containing family member 0.0117 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0023 0.0025 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0243 0.1431 0.1431
Onchocerca volvulus 0.002 0.0007 0.0003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0246 0.0246
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0246 0.0239
Echinococcus granulosus microtubule associated protein 2 0.0687 0.4268 0.4268
Schistosoma mansoni rab6-interacting 0.0019 0.0005 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0007 0.0002
Plasmodium falciparum pyruvate kinase 0.1585 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0005 0.0005
Mycobacterium ulcerans pyruvate kinase 0.1585 1 1
Onchocerca volvulus 0.002 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Schistosoma mansoni lamin 0.0031 0.0081 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Plasmodium falciparum pyruvate kinase 2 0.0813 0.5075 0.5073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0117 0.0627 0.0603
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.0627 0.062
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0218 0.0214
Brugia malayi latrophilin 2 splice variant baaae 0.0281 0.1673 0.1669
Echinococcus multilocularis lamin dm0 0.0031 0.0081 0.0081
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0065 0.0297 0.0292
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0117 0.0627 0.0622
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0025 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.042 0.2564 0.2564
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0361 0.0354
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0117 0.0627 0.0622
Brugia malayi MH2 domain containing protein 0.0376 0.228 0.2276
Toxoplasma gondii pyruvate kinase PyK1 0.1585 1 1
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0081 0.0076
Echinococcus granulosus beta LACTamase domain containing family member 0.0117 0.0627 0.0627
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0246 0.0241
Giardia lamblia Pyruvate kinase 0.1585 1 1
Brugia malayi Pre-SET motif family protein 0.003 0.0075 0.007
Schistosoma mansoni hypothetical protein 0.0697 0.4334 0.4334
Schistosoma mansoni bromodomain containing protein 0.0073 0.0345 0.0345
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0045 0.0045
Echinococcus granulosus lamin dm0 0.0031 0.0081 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0246 0.0239
Brugia malayi Latrophilin receptor protein 2 0.013 0.071 0.0706
Echinococcus multilocularis pyruvate kinase 0.0813 0.5075 0.5075
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0361 0.0354
Brugia malayi Cathepsin L-like precursor 0.002 0.0007 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0131 0.0131
Brugia malayi MH2 domain containing protein 0.0026 0.0045 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0694 0.0694
Loa Loa (eye worm) pyruvate kinase 0.1585 1 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0218 0.0214
Leishmania major DNA polymerase eta, putative 0.0023 0.0025 0.0018
Brugia malayi Cytochrome P450 family protein 0.002 0.0007 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0174 0.0174
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0746 0.4644 0.4631
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0007 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0246 0.0241
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0246 0.0241
Loa Loa (eye worm) hypothetical protein 0.0274 0.1629 0.1625
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0243 0.1431 0.1427
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0246 0.5
Echinococcus granulosus pyruvate kinase 0.0813 0.5075 0.5075
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0045 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.042 0.2564 0.2564
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0025 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Schistosoma mansoni pyruvate kinase 0.1585 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.032 0.032
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0177 0.0173
Schistosoma mansoni Smad4 0.0026 0.0045 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0243 0.1431 0.1431
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0065 0.0297 0.0292
Giardia lamblia Pyruvate kinase 0.0813 0.5075 0.5063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.0627 0.0627
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0045 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0243 0.1431 0.1427
Loa Loa (eye worm) hypothetical protein 0.0049 0.0193 0.0189
Echinococcus granulosus snurportin 1 0.0944 0.5907 0.5907
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0342 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0117 0.0627 0.0622
Echinococcus granulosus dna polymerase kappa 0.0023 0.0025 0.0025
Echinococcus multilocularis musashi 0.0031 0.0081 0.0081
Brugia malayi hypothetical protein 0.0274 0.1629 0.1625
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.1121 0.1121
Loa Loa (eye worm) hypothetical protein 0.0077 0.0374 0.0369
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0025 0.0018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0065 0.0297 0.0297
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0117 0.0627 0.0622
Echinococcus multilocularis zinc finger protein 0.0025 0.0041 0.0041
Mycobacterium tuberculosis Conserved protein 0.0117 0.0627 0.0603
Brugia malayi pyruvate kinase, muscle isozyme 0.0334 0.2013 0.2009
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.0627 0.062
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0227 0.0227
Echinococcus multilocularis cysteine protease 0.002 0.0007 0.0007
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0038 0.0038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0246 0.0246
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0135 0.011
Schistosoma mansoni transcription factor LCR-F1 0.042 0.2564 0.2564
Brugia malayi Cathepsin L-like precursor 0.002 0.0007 0.0003
Brugia malayi Cathepsin L-like precursor 0.002 0.0007 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.0627 0.062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0243 0.1431 0.1431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.013 0.071 0.071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0243 0.1431 0.1431
Brugia malayi Bromodomain containing protein 0.0045 0.0171 0.0167
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0007 0.0007
Echinococcus multilocularis cysteine protease 0.002 0.0007 0.0007
Onchocerca volvulus 0.002 0.0007 0.0003
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0117 0.0627 0.0622
Onchocerca volvulus 0.002 0.0007 0.0003
Leishmania major hypothetical protein, conserved 0.0117 0.0627 0.062
Toxoplasma gondii exonuclease III APE 0.0057 0.0246 0.0239
Trichomonas vaginalis pyruvate kinase, putative 0.1585 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0342 0.0317
Brugia malayi beta-lactamase family protein 0.0117 0.0627 0.0622
Echinococcus multilocularis dna polymerase eta 0.0023 0.0025 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0005 0.0005
Schistosoma mansoni DNA polymerase eta 0.0023 0.0025 0.0025
Onchocerca volvulus 0.0117 0.0627 0.0622
Plasmodium falciparum importin beta, putative 0.0088 0.0446 0.0441
Echinococcus multilocularis tumor protein p63 0.0342 0.2065 0.2065
Chlamydia trachomatis pyruvate kinase 0.1585 1 0.5
Brugia malayi Pyruvate kinase, M2 isozyme 0.1585 1 1
Onchocerca volvulus 0.002 0.0007 0.0003
Brugia malayi mbt repeat family protein 0.0046 0.0177 0.0173
Trypanosoma cruzi pyruvate kinase 2, putative 0.1585 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0446 0.0439
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0025 0.002
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0177 0.0177
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.228 0.2276
Loa Loa (eye worm) pyruvate kinase 0.1585 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0339 0.0332
Loa Loa (eye worm) hypothetical protein 0.012 0.0648 0.0643
Echinococcus multilocularis importin subunit beta 1 0.0088 0.0446 0.0446
Echinococcus multilocularis geminin 0.0697 0.4334 0.4334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Toxoplasma gondii HEAT repeat-containing protein 0.0088 0.0446 0.0439
Loa Loa (eye worm) hypothetical protein 0.0053 0.0218 0.0214
Mycobacterium ulcerans hypothetical protein 0.0117 0.0627 0.062
Loa Loa (eye worm) beta-lactamase 0.0117 0.0627 0.0622
Trichomonas vaginalis esterase, putative 0.0117 0.0627 0.062
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0025 0.0025
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0007 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0025 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0243 0.1431 0.1431
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0007 0.0003
Schistosoma mansoni lipoxygenase 0.0019 0.0005 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.041 0.2502 0.2498
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0117 0.0627 0.0622
Mycobacterium tuberculosis Probable lipase LipE 0.0117 0.0627 0.0603
Schistosoma mansoni rab6-interacting 0.0019 0.0005 0.0005
Schistosoma mansoni smad1 5 8 and 0.0026 0.0045 0.0045
Onchocerca volvulus 0.0031 0.0081 0.0076
Mycobacterium tuberculosis Conserved protein 0.0117 0.0627 0.0603
Loa Loa (eye worm) pyruvate kinase 0.1585 1 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0694 0.0694
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0944 0.5907 0.5905
Loa Loa (eye worm) pyruvate kinase-PB 0.1105 0.6938 0.6937
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0694 0.0694
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.013 0.071 0.071
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0342 0.0342
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0025 0.0025
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0069 0.0319 0.0312
Brugia malayi intermediate filament protein 0.0031 0.0081 0.0076
Schistosoma mansoni hypothetical protein 0.0293 0.1753 0.1753
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0246 0.0239
Echinococcus granulosus lamin 0.0031 0.0081 0.0081
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0694 0.069
Onchocerca volvulus 0.0056 0.0238 0.0233
Schistosoma mansoni hypothetical protein 0.042 0.2564 0.2564
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0246 0.0221
Schistosoma mansoni hypothetical protein 0.0281 0.1673 0.1673
Loa Loa (eye worm) hypothetical protein 0.0281 0.1673 0.1669
Echinococcus granulosus intermediate filament protein 0.0031 0.0081 0.0081
Echinococcus multilocularis pyruvate kinase 0.1585 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0188 0.0184
Echinococcus granulosus tar DNA binding protein 0.0127 0.0694 0.0694
Schistosoma mansoni hypothetical protein 0.013 0.071 0.071
Loa Loa (eye worm) latrophilin receptor protein 2 0.013 0.071 0.0706
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0065 0.0297 0.0292
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0007 0.0002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0007 0.0003
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0007 0.0003
Onchocerca volvulus 0.0117 0.0627 0.0622
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0177 0.0173
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.005 0.0201 0.0197
Schistosoma mansoni smad1 5 8 and 0.0026 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.042 0.2564 0.3689
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0025 0.002
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.228 0.2276
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0177 0.0177
Leishmania major importin beta-1 subunit, putative 0.0072 0.0339 0.0332
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0246 0.0241
Loa Loa (eye worm) CYP4Cod1 0.002 0.0007 0.0002
Mycobacterium tuberculosis Conserved protein 0.0117 0.0627 0.0603
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0005 0.0005
Echinococcus granulosus RUN 0.0019 0.0005 0.0005
Trypanosoma brucei pyruvate kinase 1 0.1585 1 1
Schistosoma mansoni ap endonuclease 0.0057 0.0246 0.0246
Mycobacterium ulcerans beta-lactamase 0.0117 0.0627 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.013 0.071 0.0706
Brugia malayi Cathepsin L-like precursor 0.002 0.0007 0.0003
Entamoeba histolytica pyruvate kinase, putative 0.1105 0.6938 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0117 0.0627 0.062
Loa Loa (eye worm) acetyltransferase 0.015 0.0838 0.0833
Onchocerca volvulus 0.0046 0.0177 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0627 0.062
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0218 0.0218
Brugia malayi TAR-binding protein 0.0127 0.0694 0.069
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0007 0.0007
Schistosoma mansoni loxhd1 0.0019 0.0005 0.0005
Brugia malayi hypothetical protein 0.012 0.0648 0.0643
Onchocerca volvulus 0.005 0.0201 0.0196
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0065 0.0297 0.029
Echinococcus granulosus cathepsin l1 0.002 0.0007 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0131 0.0131
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0065 0.0297 0.0272
Leishmania major pyruvate kinase 0.1585 1 1
Leishmania major cathepsin L-like protease 0.0075 0.0361 0.0354
Schistosoma mansoni hypothetical protein 0.013 0.071 0.071
Schistosoma mansoni ran 0.0065 0.0297 0.0297
Echinococcus granulosus smad 0.0026 0.0045 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.1585 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0065 0.0297 0.0292
Brugia malayi mbt repeat family protein 0.0046 0.0177 0.0173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.013 0.071 0.0706
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0795 0.0795
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0694 0.069
Echinococcus multilocularis pyruvate kinase 0.1251 0.7868 0.7868
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0007 0.0007
Onchocerca volvulus Cathepsin F homolog 0.002 0.0007 0.0003
Onchocerca volvulus 0.002 0.0007 0.0003
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0007 0.0007
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0025 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0201 0.0201
Echinococcus granulosus pyruvate kinase 0.1585 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0088 0.0446 0.0439
Trichomonas vaginalis ran, putative 0.0065 0.0297 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Schistosoma mansoni lipoxygenase 0.0054 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0031 0.0081 0.0076
Toxoplasma gondii pyruvate kinase PyKII 0.0813 0.5075 0.5071
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Schistosoma mansoni smad 0.0026 0.0045 0.0045
Entamoeba histolytica hypothetical protein 0.042 0.2564 0.3689
Toxoplasma gondii ABC1 family protein 0.0117 0.0627 0.062
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0117 0.0627 0.0627
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0361 0.0354
Entamoeba histolytica Ran family GTPase 0.0065 0.0297 0.0418
Trypanosoma cruzi pyruvate kinase 2, putative 0.1585 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0045 0.004
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0174 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0075 0.0075
Loa Loa (eye worm) pyruvate kinase 0.0334 0.2013 0.2009
Brugia malayi MH2 domain containing protein 0.0026 0.0045 0.004
Brugia malayi Cytochrome P450 family protein 0.002 0.0007 0.0002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Schistosoma mansoni smad1 5 8 and 0.0026 0.0045 0.0045
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0025 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0025 0.0018
Trichomonas vaginalis pyruvate kinase, putative 0.1585 1 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0479 0.2943 0.294
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0342 0.0335
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0361 0.0354
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0243 0.1431 0.1431
Schistosoma mansoni polycystin 1-related 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0003
Echinococcus granulosus pyruvate kinase 0.1585 1 1
Echinococcus multilocularis RUN 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.005 0.0201 0.0196
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.013 0.071 0.071
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0838 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Echinococcus multilocularis pyruvate kinase 0.1585 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Brugia malayi RNA binding protein 0.0127 0.0694 0.069
Schistosoma mansoni hypothetical protein 0.0944 0.5907 0.5907
Plasmodium vivax vivapain-2 0.002 0.0007 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.041 0.2502 0.2498
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0135 0.013
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0025 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0193 0.0193
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0193 0.0193
Echinococcus multilocularis lamin 0.0031 0.0081 0.0081
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0038 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0075 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0342 0.0335
Echinococcus granulosus dna polymerase eta 0.0023 0.0025 0.0025
Trypanosoma brucei pyruvate kinase 1, putative 0.1585 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0117 0.0627 0.0622
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0246 0.5
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0246 0.0239
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0342 0.0342
Onchocerca volvulus 0.0031 0.0081 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0177 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0243 0.1431 0.1431
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0072
Onchocerca volvulus Pyruvate kinase homolog 0.1585 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0117 0.0627 0.062
Brugia malayi beta-lactamase 0.0117 0.0627 0.0622
Schistosoma mansoni lamin 0.0031 0.0081 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0174 0.0167
Brugia malayi Cathepsin L-like precursor 0.002 0.0007 0.0003
Loa Loa (eye worm) ctsf protein 0.002 0.0007 0.0003
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0177 0.0177
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0117 0.0627 0.0603
Loa Loa (eye worm) cysteine protease 0.002 0.0007 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0025 0.0018
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0218 0.0218
Mycobacterium ulcerans esterase/lipase LipP 0.0117 0.0627 0.062
Echinococcus granulosus importin subunit beta 1 0.0088 0.0446 0.0446
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0227 0.0227
Trichomonas vaginalis set domain proteins, putative 0.024 0.1415 0.1409
Echinococcus granulosus tumor protein p63 0.0342 0.2065 0.2065
Entamoeba histolytica hypothetical protein 0.042 0.2564 0.3689
Echinococcus granulosus pyruvate kinase 0.0813 0.5075 0.5075
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0342 0.0335
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0045 0.0045
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0045 0.004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0065 0.0297 0.0297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0342 0.0335
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0038 0.0038
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0027 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0246 0.0239
Schistosoma mansoni ap endonuclease 0.0057 0.0246 0.0246
Onchocerca volvulus Pyruvate kinase homolog 0.1585 1 1
Echinococcus multilocularis pyruvate kinase 0.0813 0.5075 0.5075
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0025 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0694 0.0694
Brugia malayi pyruvate kinase 0.0334 0.2013 0.2009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0218 0.0218
Onchocerca volvulus Cathepsin L homolog 0.002 0.0007 0.0003
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0005 0.0005
Echinococcus granulosus geminin 0.0697 0.4334 0.4334
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.4268 0.4268
Trypanosoma brucei unspecified product 0.0023 0.0025 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0117 0.0627 0.062
Echinococcus multilocularis GPCR, family 2 0.013 0.071 0.071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.1121 0.1121
Brugia malayi MH1 domain containing protein 0.0026 0.0045 0.004
Onchocerca volvulus Huntingtin homolog 0.012 0.0648 0.0643
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0144
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.1229 0.1225
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0072 0.0339 0.0332
Echinococcus granulosus GPCR family 2 0.013 0.071 0.071
Schistosoma mansoni ran 0.0065 0.0297 0.0297
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Schistosoma mansoni survival motor neuron protein 0.0056 0.0238 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.1629 0.1629
Echinococcus multilocularis smad 0.0026 0.0045 0.0045
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0258 0.0251
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0081 0.0076
Plasmodium vivax vivapain-2 0.002 0.0007 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0117 0.0627 0.062
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0246 0.0239
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0246 0.0239
Schistosoma mansoni importin beta-1 0.0088 0.0446 0.0446
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0067 0.0067
Brugia malayi Importin beta-1 subunit 0.0088 0.0446 0.0441
Loa Loa (eye worm) hypothetical protein 0.1105 0.6938 0.6937
Onchocerca volvulus Pyruvate kinase homolog 0.1585 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0446 0.0441
Onchocerca volvulus Cathepsin L homolog 0.002 0.0007 0.0003
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0838 0.0833
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.032 0.032
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0135 0.0184
Plasmodium vivax SET domain protein, putative 0.003 0.0075 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0075
Onchocerca volvulus 0.0117 0.0627 0.0622
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0174 0.0167
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.1629 0.1629
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0065 0.0297 0.029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Onchocerca volvulus 0.003 0.0075 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Schistosoma mansoni hypothetical protein 0.0697 0.4334 0.4334
Leishmania major DNA polymerase kappa, putative 0.0023 0.0025 0.0018
Echinococcus granulosus pyruvate kinase 0.0813 0.5075 0.5075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0238 0.0233
Mycobacterium leprae Probable pyruvate kinase PykA 0.1585 1 1
Schistosoma mansoni hypothetical protein 0.0056 0.0238 0.0238
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0117 0.0627 0.0603
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0838 0.0838
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0025 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.4268 0.4268
Brugia malayi MH1 domain containing protein 0.0026 0.0045 0.004
Mycobacterium ulcerans lipase LipD 0.0117 0.0627 0.062
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0065 0.0297 0.029
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0193 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.041 0.2502 0.2498
Plasmodium vivax pyruvate kinase, putative 0.1585 1 1
Schistosoma mansoni pyruvate kinase 0.1585 1 1
Leishmania major pyruvate kinase 0.1585 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0117 0.0627 0.0603
Brugia malayi Bromodomain containing protein 0.0085 0.0427 0.0422
Plasmodium vivax pyruvate kinase 2, putative 0.0813 0.5075 0.5073
Leishmania major cathepsin L-like protease 0.0075 0.0361 0.0354
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0177 0.0177
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0075 0.0067
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0025 0.0025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0007 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0361 0.0354
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0246 0.0344
Entamoeba histolytica hypothetical protein 0.042 0.2564 0.3689
Onchocerca volvulus 0.002 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0117 0.0627 0.0622
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0694 0.0694
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0177 0.0177
Brugia malayi Smad1 0.0026 0.0045 0.004
Echinococcus granulosus zinc finger protein 0.0025 0.0041 0.0041
Trichomonas vaginalis importin beta-1, putative 0.0072 0.0339 0.0332
Plasmodium vivax importin-beta 2, putative 0.0088 0.0446 0.0441
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.013 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0117 0.0627 0.0622
Onchocerca volvulus Huntingtin homolog 0.012 0.0648 0.0643
Leishmania major GTP-binding protein, putative 0.0065 0.0297 0.029
Echinococcus granulosus Smad4 0.0026 0.0045 0.0045
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0007 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0694 0.069
Loa Loa (eye worm) fibroinase 0.002 0.0007 0.0003
Leishmania major cathepsin L-like protease 0.0075 0.0361 0.0354
Brugia malayi hypothetical protein 0.042 0.2564 0.256
Schistosoma mansoni intermediate filament proteins 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.041 0.2502 0.2498
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0177 0.0177
Brugia malayi RNA, U transporter 1 0.0251 0.1486 0.1483
Brugia malayi Pre-SET motif family protein 0.0211 0.1229 0.1225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0342 0.0335
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0218 0.0218
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0193 0.0193
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0081 0.0076
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0007 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0074 0.0069
Echinococcus multilocularis pyruvate kinase 0.0813 0.5075 0.5075
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0342 0.0342
Schistosoma mansoni hypothetical protein 0.013 0.071 0.071
Brugia malayi PHD-finger family protein 0.0031 0.0078 0.0073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0025 0.0025
Schistosoma mansoni zinc finger protein 0.0025 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.013 0.071 0.071
Loa Loa (eye worm) RNA binding protein 0.0127 0.0694 0.069
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0174 0.0167
Entamoeba histolytica hypothetical protein 0.0072 0.0339 0.0479
Echinococcus multilocularis Smad4 0.0026 0.0045 0.0045
Brugia malayi Cytochrome P450 family protein 0.003 0.0074 0.0069
Echinococcus multilocularis snurportin 1 0.0944 0.5907 0.5907
Trypanosoma cruzi importin beta-1 subunit, putative 0.0072 0.0339 0.0332
Loa Loa (eye worm) hypothetical protein 0.0046 0.0177 0.0173
Brugia malayi beta-lactamase family protein 0.0117 0.0627 0.0622
Schistosoma mansoni pyruvate kinase 0.0813 0.5075 0.5075
Mycobacterium tuberculosis Probable lipase LipD 0.0117 0.0627 0.0603
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0174 0.017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0246 0.0221
Brugia malayi Cathepsin L-like precursor 0.002 0.0007 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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