Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0164 | 0.0499 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1716 | 0.5199 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0008 | 0.0018 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1716 | 0.5199 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1716 | 0.5225 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0164 | 0.0146 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0164 | 0.0146 |
Onchocerca volvulus | 0.0011 | 0.0164 | 0.0146 | |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1716 | 0.5225 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1716 | 0.1702 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3285 | 0.3273 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0164 | 0.0499 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0164 | 0.0146 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0164 | 0.0447 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 1 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0164 | 0.0499 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0164 | 0.0146 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0164 | 0.5 |
Schistosoma mansoni | ras GTP exchange factor | 0.0008 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.