TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 630.777 | Formula: C35H46N6O5
H donors: 4 H acceptors: 5 LogP: 2.69 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H](N1C[C@H](C)[C@@H](CN(Cc2ccncc2)C)Oc2c(C1=O)cccc2NC(=O)CCCCCC(=O)Nc1ccccc1N)C
InChi: 1S/C35H46N6O5/c1-24-20-41(25(2)23-42)35(45)27-10-9-13-30(34(27)46-31(24)22-40(3)21-26-16-18-37-19-17-26)39-33(44)15-6-4-5-14-32(43)38-29-12-8-7-11-28(29)36/h7-13,16-19,24-25,31,42H,4-6,14-15,20-23,36H2,1-3H3,(H,38,43)(H,39,44)/t24-,25+,31+/m0/s1
InChiKey: YTGCLJURRTWXGQ-NVDQFQLTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.1789	0.4321
Entamoeba histolytica	protein kinase rad3, putative	0.0009	0.0005	0.0011
Echinococcus granulosus	tar DNA binding protein	0.0057	0.2548	0.6154
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0017	0.0401	0.0827
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0017	0.0401	0.0957
Schistosoma mansoni	hypothetical protein	0.0033	0.1299	0.1299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0023	0.074	0.074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.1789	0.1789
Plasmodium falciparum	ataxin-2 like protein, putative	0.0066	0.3037	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.1078	0.2378
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.001
Onchocerca volvulus	Peroxidase homolog	0.0083	0.3957	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1811	0.3997
Echinococcus multilocularis	tar DNA binding protein	0.0057	0.2548	0.6154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.074	0.1787
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3957	0.8732
Loa Loa (eye worm)	phosphatidylinositol 3	0.0017	0.0401	0.0884
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Onchocerca volvulus	Chorion peroxidase homolog	0.0083	0.3957	0.9558
Schistosoma mansoni	hypothetical protein	0.0014	0.0226	0.0226
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.2548	0.2548
Brugia malayi	hypothetical protein	0.0042	0.1781	0.393
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0017	0.0401	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3037	0.6702
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3957	0.8732
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.1789	0.4321
Brugia malayi	hypothetical protein	0.0066	0.3037	0.6702
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.2548	0.2548
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.2548	0.2548
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.1789	0.3947
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.1811	0.3997
Trypanosoma cruzi	polo-like protein kinase, putative	0.0086	0.414	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0009	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0063	0.0153
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3957	0.8732
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0017	0.0401	0.0968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Echinococcus multilocularis	serine protein kinase ATM	0.0023	0.074	0.1787
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.1789	0.3947
Echinococcus multilocularis	GPCR, family 2	0.0014	0.0226	0.0547
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0017	0.0401	0.0957
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Onchocerca volvulus		0.0083	0.3957	0.9558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0009	0.0005	0.0005
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0029	0.1082	0.2615
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0017	0.0401	0.0827
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0017	0.0401	0.1319
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Brugia malayi	Latrophilin receptor protein 2	0.0014	0.0226	0.05
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0033	0.1299	0.3137
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.2548	0.2548
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0023	0.074	0.1632
Trypanosoma cruzi	polo-like protein kinase, putative	0.0086	0.414	1
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Brugia malayi	RNA binding protein	0.0057	0.2548	0.5622
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0017	0.0401	0.0401
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0009	0	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.0066	0.3037	1
Echinococcus multilocularis	peroxidasin	0.0083	0.3957	0.9558
Onchocerca volvulus		0.0083	0.3957	0.9558
Schistosoma mansoni	serine/threonine protein kinase	0.0086	0.414	0.414
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0086	0.414	0.9135
Onchocerca volvulus	Dual oxidase homolog	0.0083	0.3957	0.9558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0017	0.0401	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0063	0.014
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	CAMK family protein kinase	0.0043	0.1793	0.4332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Loa Loa (eye worm)	MH2 domain-containing protein	0.0093	0.4532	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0401	0.0884
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0086	0.414	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.1789	0.1789
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0011	0.0063	0.0208
Loa Loa (eye worm)	phosphatidylinositol 3	0.0017	0.0401	0.0884
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0017	0.0401	0.0968
Trypanosoma brucei	PAB1-binding protein , putative	0.0066	0.3037	0.7295
Trypanosoma cruzi	target of rapamycin kinase 3	0.0017	0.0401	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Brugia malayi	RNA recognition motif domain containing protein	0.0057	0.2548	0.5622
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.1811	0.3997
Trypanosoma brucei	polo-like protein kinase	0.0086	0.414	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0009	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Echinococcus granulosus	GPCR family 2	0.0014	0.0226	0.0547
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0086	0.414	1
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.3957	0.9558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0017	0.0402	0.0972
Onchocerca volvulus	Peroxidase homolog	0.0083	0.3957	0.9558
Brugia malayi	hypothetical protein	0.0033	0.1299	0.2866
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0023	0.074	0.1659
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0029	0.1082	0.2615
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0017	0.0401	0.0968
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0023	0.074	0.1777
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Entamoeba histolytica	hypothetical protein	0.0033	0.1299	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0086	0.414	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0014	0.0226	0.05
Schistosoma mansoni	hypothetical protein	0.0029	0.1078	0.1078
Entamoeba histolytica	hypothetical protein	0.0023	0.074	0.1787
Loa Loa (eye worm)	transcription factor SMAD2	0.0093	0.4532	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.1789	0.4321
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.1789	0.4321
Trypanosoma cruzi	PAB1-binding protein , putative	0.0066	0.3037	0.7333
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Echinococcus granulosus	peroxidasin	0.0083	0.3957	0.9558
Schistosoma mansoni	hypothetical protein	0.0029	0.1082	0.1082
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0017	0.0401	0.0957
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.1078	0.2378
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Schistosoma mansoni	hypothetical protein	0.0014	0.0226	0.0226
Entamoeba histolytica	hypothetical protein	0.0033	0.1299	0.3137
Trypanosoma cruzi	PAB1-binding protein , putative	0.0066	0.3037	0.7333
Loa Loa (eye worm)	blistered cuticle protein 3	0.0083	0.3957	0.8732
Plasmodium falciparum	ataxin-2 like protein, putative	0.0066	0.3037	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0009	0.0005	0.001
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0017	0.0401	0.0827
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0017	0.0401	0.0957
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0017	0.0401	0.0827
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0009	0.0005	0.0011
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0057	0.2548	0.5622
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0063	0.0153
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0009	0.0005	0.0011
Entamoeba histolytica	hypothetical protein	0.0033	0.1299	0.3137
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Schistosoma mansoni	peroxidasin	0.0083	0.3957	0.3957
Echinococcus granulosus	serine protein kinase ATM	0.0023	0.074	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0226	0.05
Brugia malayi	Blistered cuticle protein 3	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Onchocerca volvulus		0.0083	0.3957	0.9558
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0086	0.414	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.002	0.0565	0.1355
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0017	0.0402	0.0961
Toxoplasma gondii	FATC domain-containing protein	0.0023	0.074	0.2435
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0017	0.0401	0.0827
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3957	0.8732
Loa Loa (eye worm)	RNA binding protein	0.0057	0.2548	0.5622
Schistosoma mansoni	tar DNA-binding protein	0.0057	0.2548	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Loa Loa (eye worm)	hypothetical protein	0.002	0.0565	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0086	0.414	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0017	0.0401	0.0968
Brugia malayi	MH2 domain containing protein	0.0093	0.4532	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0066	0.3037	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0017	0.0401	0.0968
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0017	0.0401	0.0401
Leishmania major	hypothetical protein, conserved	0.0066	0.3037	0.7336
Brugia malayi	hypothetical protein	0.0083	0.3957	0.8732
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0033	0.1299	0.3137
Trichomonas vaginalis	CAMK family protein kinase	0.0043	0.1793	0.4332
Trichomonas vaginalis	CAMK family protein kinase	0.0086	0.414	1
Brugia malayi	Peroxidasin	0.0083	0.3957	0.8732
Brugia malayi	TAR-binding protein	0.0057	0.2548	0.5622
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0014	0.0226	0.0547
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Entamoeba histolytica	hypothetical protein	0.0033	0.1299	0.3137
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0014	0.0226	0.0547
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0401	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0083	0.3957	0.8732
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0014	0.0226	0.05
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.3957	0.8732
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0009	0.0005	0.0011
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.3957	0.9558
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0017	0.0401	0.0968
Schistosoma mansoni	hypothetical protein	0.0014	0.0226	0.0226
Loa Loa (eye worm)	TAR-binding protein	0.0057	0.2548	0.5622
Brugia malayi	serine/threonine-protein kinase plk-2	0.0086	0.414	0.9135
Schistosoma mansoni	kinase	0.0044	0.1855	0.1855
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0014	0.0226	0.0547
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0401	0.0884
Giardia lamblia	Kinase, PLK	0.0086	0.414	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0017	0.0401	0.0968
Schistosoma mansoni	transcription factor LCR-F1	0.0033	0.1299	0.1299
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.1789	0.1789
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.1811	0.3997
Schistosoma mansoni	peroxidasin	0.0083	0.3957	0.3957
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0014	0.0226	0.0547
Schistosoma mansoni	hypothetical protein	0.0014	0.0226	0.0226
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0017	0.0401	0.0968
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0017	0.0401	0.0968

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2136031

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1711714