TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 457.473 | Formula: C23H25F2N5O3
H donors: 3 H acceptors: 4 LogP: 2.95 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H](CCn2nnc(c2)c2ccc(cc2)F)CC[C@H]1NC(=O)Nc1ccc(cc1)F
InChi: 1S/C23H25F2N5O3/c24-16-3-1-15(2-4-16)21-13-30(29-28-21)12-11-19-9-10-20(22(14-31)33-19)27-23(32)26-18-7-5-17(25)6-8-18/h1-8,13,19-20,22,31H,9-12,14H2,(H2,26,27,32)/t19-,20+,22+/m0/s1
InChiKey: JLBHWNUEZALAQX-TUNNFDKTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	RNA, U transporter 1	0.0081	0.0377	0.0377
Onchocerca volvulus	Chorion peroxidase homolog	0.0712	0.4889	0.9883
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Echinococcus multilocularis	protein jagged 1	0.0037	0.006	0.006
Brugia malayi	Calcium binding EGF domain containing protein	0.0037	0.006	0.006
Brugia malayi	Animal haem peroxidase family protein	0.0712	0.4889	0.4889
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.0172	0.1026	0.5
Schistosoma mansoni	notch	0.0037	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0306	0.1981	0.1981
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0172	0.1026	0.5
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	notch-like transmembrane receptor	0.0037	0.006	0.006
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0342	0.0342
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0172	0.1026	0.5
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0037	0.006	0.006
Echinococcus multilocularis	protein jagged 2	0.0037	0.006	0.006
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0172	0.1026	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0342	0.0342
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0031	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0019	0.0019
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0342	0.0342
Mycobacterium ulcerans	amidase	0.0172	0.1026	0.5
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0172	0.1026	0.5
Echinococcus granulosus	notch	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0092	0.0092
Echinococcus granulosus	neurogenic locus notch protein 4	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Onchocerca volvulus	Tyrosine kinase homolog	0.0475	0.3191	0.6408
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0677	0.1262
Echinococcus multilocularis	peroxidasin	0.073	0.5019	0.5019
Brugia malayi	GCC2 and GCC3 family protein	0.0037	0.006	0.006
Echinococcus multilocularis	protein jagged 1	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Echinococcus multilocularis	fibropellin Ia	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Echinococcus granulosus	protein jagged 1	0.0037	0.006	0.006
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0342	0.0342
Onchocerca volvulus	Dual oxidase homolog	0.0712	0.4889	0.9883
Mycobacterium ulcerans	amidase	0.0172	0.1026	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0342	0.0342
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0172	0.1026	0.1026
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0172	0.1026	0.5
Onchocerca volvulus		0.0712	0.4889	0.9883
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0172	0.1026	0.1026
Schistosoma mansoni	vesicular amine transporter	0.0031	0.0019	0.0019
Brugia malayi	Peroxidasin	0.073	0.5019	0.5019
Schistosoma mansoni	fatty-acid amide hydrolase	0.1427	1	1
Onchocerca volvulus		0.0712	0.4889	0.9883
Trypanosoma cruzi	amidase, putative	0.0172	0.1026	0.5
Brugia malayi	Animal haem peroxidase family protein	0.072	0.4946	0.4946
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Echinococcus multilocularis	neurogenic locus notch protein	0.0037	0.006	0.006
Echinococcus multilocularis	neural cadherin	0.0037	0.006	0.006
Loa Loa (eye worm)	animal heme peroxidase	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	putative amidase	0.0172	0.1026	0.1026
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0342	0.0342
Echinococcus granulosus	neurogenic locus notch protein	0.0037	0.006	0.006
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0172	0.1026	1
Echinococcus granulosus	peroxidasin	0.073	0.5019	0.5019
Brugia malayi	Animal haem peroxidase family protein	0.0712	0.4889	0.4889
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0172	0.1026	0.5
Mycobacterium ulcerans	amidase	0.0172	0.1026	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Echinococcus granulosus	protein jagged 2	0.0037	0.006	0.006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0019	0.0019
Onchocerca volvulus	Peroxidase homolog	0.0712	0.4889	0.9883
Schistosoma mansoni	nephrin	0.0039	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Echinococcus multilocularis	Immunoglobulin	0.0031	0.0019	0.0019
Echinococcus multilocularis	snurportin 1	0.0306	0.1981	0.1981
Onchocerca volvulus	Peroxidasin homolog	0.072	0.4946	1
Echinococcus granulosus	slit 2 protein	0.0037	0.006	0.006
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0342	0.0342
Echinococcus multilocularis	slit 2 protein	0.0037	0.006	0.006
Brugia malayi	Animal haem peroxidase family protein	0.0712	0.4889	0.4889
Mycobacterium ulcerans	amidase	0.0172	0.1026	0.5
Brugia malayi	Delta serrate ligand family protein	0.0037	0.006	0.006
Toxoplasma gondii	EGF family domain-containing protein	0.0037	0.006	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0677	0.0677
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.0172	0.1026	0.5
Echinococcus granulosus	neural cadherin	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Schistosoma mansoni	amidase	0.1427	1	1
Echinococcus granulosus	snurportin 1	0.0306	0.1981	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0508	0.3431	0.3431
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Schistosoma mansoni	notch	0.0037	0.006	0.006
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0172	0.1026	0.1026
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1427	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	Calcium binding EGF domain containing protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0149	0.0149
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0508	0.3431	0.3431
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Echinococcus multilocularis	neuroglian	0.0039	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Brugia malayi	Animal haem peroxidase family protein	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Schistosoma mansoni	notch	0.0037	0.006	0.006
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.1427	1	1
Echinococcus granulosus	twitchin	0.0039	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Echinococcus granulosus	neuroglian	0.0039	0.0076	0.0076
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Schistosoma mansoni	notch	0.0037	0.006	0.006
Echinococcus granulosus	protein jagged 2	0.0037	0.006	0.006
Onchocerca volvulus		0.0712	0.4889	0.9883
Brugia malayi	hypothetical protein	0.0031	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0041	0.0092	0.0092
Schistosoma mansoni	notch	0.0037	0.006	0.006
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0037	0.006	0.006
Echinococcus multilocularis	roundabout 2	0.0049	0.0149	0.0149
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0031	0.0019	0.0019
Mycobacterium ulcerans	peptide amidase, GatA	0.0172	0.1026	0.5
Mycobacterium ulcerans	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0172	0.1026	0.5
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0172	0.1026	0.1026
Echinococcus multilocularis	neurogenic locus protein delta	0.0037	0.006	0.006
Brugia malayi	Cadherin domain containing protein	0.0037	0.006	0.006
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0342	0.0342
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	animal heme peroxidase	0.0712	0.4889	0.4889
Giardia lamblia	High cysteine protein	0.0037	0.006	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0019	0.0019
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0172	0.1026	0.5
Leishmania major	hypothetical protein, conserved	0.0172	0.1026	0.5
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Schistosoma mansoni	notch	0.0037	0.006	0.006
Schistosoma mansoni	cell adhesion molecule	0.0041	0.0092	0.0092
Schistosoma mansoni	cell polarity protein	0.0037	0.006	0.006
Echinococcus granulosus	fibropellin Ia	0.0037	0.006	0.006
Loa Loa (eye worm)	animal heme peroxidase	0.072	0.4946	0.4946
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0037	0.006	0.006
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0037	0.006	0.006
Brugia malayi	hypothetical protein	0.0712	0.4889	0.4889
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	amidase	0.0172	0.1026	0.1026
Schistosoma mansoni	septate junction protein	0.0037	0.006	0.006
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0172	0.1026	0.1026
Loa Loa (eye worm)	hypothetical protein	0.1427	1	1
Schistosoma mansoni	slit	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	hypothetical protein	0.0123	0.0677	0.0677
Brugia malayi	TAR-binding protein	0.0076	0.0342	0.0342
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0172	0.1026	0.5
Brugia malayi	Amidase family protein	0.0172	0.1026	0.1026
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0031	0.0019	0.0019
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1427	1	1
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Brugia malayi	Blistered cuticle protein 3	0.0712	0.4889	0.4889
Loa Loa (eye worm)	blistered cuticle protein 3	0.0712	0.4889	0.4889
Echinococcus granulosus	delta-like protein 1	0.0037	0.006	0.006
Schistosoma mansoni	peroxidasin	0.0722	0.4962	0.4962
Onchocerca volvulus	Peroxidase homolog	0.0712	0.4889	0.9883
Loa Loa (eye worm)	notch protein	0.0037	0.006	0.006
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Echinococcus granulosus	roundabout 2	0.0049	0.0149	0.0149
Echinococcus granulosus	defective proboscis extension response	0.0031	0.0019	0.0019
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Echinococcus multilocularis	neurogenic locus notch protein	0.0037	0.006	0.006
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Brugia malayi	Muscle positioning protein 4	0.0037	0.006	0.006
Loa Loa (eye worm)	amidase	0.0172	0.1026	0.1026
Brugia malayi	Amidase family protein	0.0172	0.1026	0.1026
Mycobacterium ulcerans	amidase	0.0172	0.1026	0.5
Trypanosoma cruzi	amidase, putative	0.0172	0.1026	0.5
Schistosoma mansoni	hypothetical protein	0.0037	0.006	0.006
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0342	0.0342
Onchocerca volvulus	Huntingtin homolog	0.0123	0.0677	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Echinococcus granulosus	protein jagged 1	0.0037	0.006	0.006
Echinococcus multilocularis	neurogenic locus protein delta	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Brugia malayi	RNA binding protein	0.0076	0.0342	0.0342
Echinococcus granulosus	neurogenic locus protein delta	0.0037	0.006	0.006
Schistosoma mansoni	fatty-acid amide hydrolase	0.0172	0.1026	0.1026
Loa Loa (eye worm)	Notch2	0.0037	0.006	0.006
Loa Loa (eye worm)	animal heme peroxidase	0.0712	0.4889	0.4889
Loa Loa (eye worm)	hypothetical protein	0.073	0.5019	0.5019
Echinococcus granulosus	neurogenic locus notch protein	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0712	0.4889	0.4889
Brugia malayi	EGF-like domain containing protein	0.0037	0.006	0.006
Schistosoma mansoni	peroxidasin	0.0712	0.4889	0.4889
Echinococcus multilocularis	Immunoglobulin	0.0031	0.0019	0.0019
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0172	0.1026	1
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0172	0.1026	0.5
Echinococcus granulosus	fatty acid amide hydrolase 1	0.1427	1	1
Echinococcus multilocularis	notch	0.0037	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0037	0.006	0.006
Echinococcus granulosus	Immunoglobulin	0.0031	0.0019	0.0019
Onchocerca volvulus		0.0464	0.3114	0.6249
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.1981	0.1981
Schistosoma mansoni	laminin gamma-3 chain	0.0037	0.006	0.006
Brugia malayi	Cadherin domain containing protein	0.0037	0.006	0.006
Onchocerca volvulus	Peroxidasin homolog	0.072	0.4946	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0037	0.006	0.006

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.5849 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2132293

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1711923