TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.441 | Formula: C24H21N3O4
H donors: 2 H acceptors: 4 LogP: 2.62 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1ccc(cc1)c1ccnc2c1CC(O2)C(=O)Nc1cccc(c1)C(=O)C
InChi: 1S/C24H21N3O4/c1-14(28)17-4-3-5-19(12-17)27-23(30)22-13-21-20(10-11-25-24(21)31-22)16-6-8-18(9-7-16)26-15(2)29/h3-12,22H,13H2,1-2H3,(H,26,29)(H,27,30)
InChiKey: UZBOOLWNBGDICB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0923	0.3652	0.3133
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2299	1	1
Schistosoma mansoni	adapter molecule crk	0.1376	0.574	0.5392
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1376	0.574	0.5392
Entamoeba histolytica	SH2 domain containing protein	0.1376	0.574	0.574
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	serine/threonine kinase, putative	0.0923	0.3652	0.3652
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	hypothetical protein	0.1376	0.574	0.5392
Echinococcus granulosus	insulin receptor	0.0923	0.3652	0.3133
Echinococcus granulosus	protein tyrosine kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	ankyrin repeat protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Echinococcus multilocularis	tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2299	1	1
Onchocerca volvulus		0.2299	1	1
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	activated cdc42 kinase 1	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Echinococcus granulosus	raf serine:threonine protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	SH2 motif	0.1376	0.574	0.5392
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	CAMK family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Plasmodium falciparum	protein kinase, putative	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	NCK adaptor protein	0.1376	0.574	0.5392
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2299	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Onchocerca volvulus		0.2299	1	1
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	serine/threonine kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1376	0.574	0.5392
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Echinococcus multilocularis	transfer RNA-Thr	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2299	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1376	0.574	0.5392
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	tyrosin kinase, putative	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.2299	1	1
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Schistosoma mansoni	nck2/grb4	0.1376	0.574	0.5392
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	AGC family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Brugia malayi	ephrin receptor 1 precursor	0.0923	0.3652	0.3133
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein kinase Blk	0.2299	1	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1376	0.574	0.5392
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK/CSK protein kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.2299	1	1
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Leishmania major	protein kinase, putative	0.0923	0.3652	0.5
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1376	0.574	0.5392
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1376	0.574	0.574
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Schistosoma mansoni	serine/threonine protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	protein kinase atn1, putative	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2299	1	1
Echinococcus granulosus	tensin	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0923	0.3652	0.3133
Entamoeba histolytica	receptor protein kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0923	0.3652	0.3133
Onchocerca volvulus		0.1376	0.574	0.329
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1376	0.574	0.5392
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0923	0.3652	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2299	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1376	0.574	0.329
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.2299	1	1
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1376	0.574	0.5392
Echinococcus multilocularis	SH2 motif	0.1376	0.574	0.5392
Schistosoma mansoni	serine/threonine protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine kinase	0.2299	1	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Plasmodium vivax	protein kinase, putative	0.0923	0.3652	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2299	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Schistosoma mansoni	tensin-related	0.1376	0.574	0.5392
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0923	0.3652	0.3133
Entamoeba histolytica	serine/threonine kinase, putative	0.0923	0.3652	0.3652
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Schistosoma mansoni	suppressor of cytokine signaling	0.1376	0.574	0.5392
Echinococcus granulosus	epidermal growth factor receptor	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0923	0.3652	0.3133
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0923	0.3652	1
Schistosoma mansoni	tensin	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1376	0.574	0.5392
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0923	0.3652	1
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0923	0.3652	0.3133
Onchocerca volvulus		0.1376	0.574	0.329
Entamoeba histolytica	tyrosin kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	SH2 motif	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.2299	1	1
Onchocerca volvulus		0.2299	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2299	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2299	1	1
Onchocerca volvulus		0.1376	0.574	0.329
Brugia malayi	Furin-like cysteine rich region family protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.2299	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2299	1	1
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	N chimaerin	0.1376	0.574	0.5392
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2299	1	1
Entamoeba histolytica	ankyrin repeat protein	0.0923	0.3652	0.3652
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Schistosoma mansoni	vav2	0.1376	0.574	0.5392
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0923	0.3652	0.3133
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1376	0.574	0.5392
Loa Loa (eye worm)	SH2 domain-containing protein	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	GTPase activating protein	0.1376	0.574	0.5392
Schistosoma mansoni	shc transforming protein	0.1376	0.574	0.5392
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0923	0.3652	0.3133
Echinococcus multilocularis	SH2 motif	0.1376	0.574	0.5392
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0296	0.0756	0.0756
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0923	0.3652	0.3133
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1376	0.574	0.5392
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0923	0.3652	0.3133
Entamoeba histolytica	tyrosin kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	tyrosine kinase	0.2299	1	1
Brugia malayi	hypothetical protein	0.2299	1	1
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Variant SH3 domain containing protein	0.1376	0.574	0.5392
Echinococcus multilocularis	heat shock protein 70	0.0923	0.3652	0.3133
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	serine/threonine RGC	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0923	0.3652	0.3133
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2299	1	1
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Brugia malayi	SH2 domain containing protein	0.2299	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Echinococcus granulosus	tyrosine protein kinase HCK	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0923	0.3652	0.3133
Brugia malayi	C-terminal src kinase protein 1	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	ephrin receptor	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2299	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/RYK protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	hypothetical protein	0.0296	0.0756	0.0756
Schistosoma mansoni	signal transduction protein lnk-related	0.1376	0.574	0.5392
Onchocerca volvulus		0.2299	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0923	0.3652	0.5
Onchocerca volvulus		0.2299	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0923	0.3652	0.3133
Trypanosoma cruzi	protein kinase, putative	0.0923	0.3652	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.2299	1	1
Schistosoma mansoni	tensin	0.1376	0.574	0.5392
Trichomonas vaginalis	TK family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2299	1	1
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0923	0.3652	1
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	protein tyrosine kinase	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.2299	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Schistosoma mansoni	tensin-related	0.1376	0.574	0.5392
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Brugia malayi	hypothetical protein	0.0923	0.3652	0.3133
Brugia malayi	hypothetical protein	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Entamoeba histolytica	hypothetical protein, conserved	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	serine/threonine kinase, putative	0.0923	0.3652	0.3652
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1376	0.574	0.5392
Echinococcus multilocularis	tensin	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Brugia malayi	Tensin	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Brugia malayi	Tyrosine-protein kinase abl-1	0.2299	1	1
Echinococcus granulosus	tyrosine kinase	0.2299	1	1
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1376	0.574	0.5392
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Echinococcus granulosus	kinase suppressor of Ras 1	0.0923	0.3652	0.3133
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2299	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0923	0.3652	0.3133
Brugia malayi	SH2 domain containing protein	0.2299	1	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1376	0.574	0.5392
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Loa Loa (eye worm)	SH2 domain-containing protein	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0923	0.3652	1
Schistosoma mansoni	serine/threonine protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1376	0.574	0.5392
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0923	0.3652	0.3133
Trypanosoma brucei	protein kinase, putative	0.0923	0.3652	1
Echinococcus multilocularis	NCK adaptor protein	0.1376	0.574	0.5392
Onchocerca volvulus		0.1376	0.574	0.329
Brugia malayi	Tyrosine-protein kinase PR2	0.0923	0.3652	0.3133
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Brugia malayi	RhoGAP domain containing protein	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK/ACK protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.1376	0.574	0.5392
Schistosoma mansoni	tyrosine kinase	0.2299	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2299	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2299	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Brugia malayi	Guanylyl cyclase protein 23	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.2299	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0923	0.3652	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Onchocerca volvulus		0.2299	1	1
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Giardia lamblia	Kinase	0.0923	0.3652	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	receptor protein kinase, putative	0.0923	0.3652	0.3652
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	activin receptor type	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase shark	0.2299	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0923	0.3652	1
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Giardia lamblia	Kinase, NEK	0.0923	0.3652	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2299	1	1
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Leishmania major	protein kinase, putative	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Brugia malayi	Variant SH3 domain containing protein	0.1376	0.574	0.5392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1376	0.574	0.5392
Echinococcus granulosus	receptor type guanylyl cyclase	0.0923	0.3652	0.3133
Schistosoma mansoni	growth factor receptor-bound protein	0.1376	0.574	0.5392
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0923	0.3652	0.3133
Loa Loa (eye worm)	SH2 domain-containing protein	0.1376	0.574	0.5392
Giardia lamblia	Kinase, NEK	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0923	0.3652	0.3133
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2299	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1376	0.574	0.329
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Leishmania major	hypothetical protein, conserved	0.0923	0.3652	0.5
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Giardia lamblia	Protein 21.1	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0923	0.3652	0.3133
Echinococcus granulosus	SH2 motif	0.1376	0.574	0.5392
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Toxoplasma gondii	STE kinase	0.0923	0.3652	1
Echinococcus multilocularis	insulin receptor	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1376	0.574	0.5392
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0923	0.3652	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1376	0.574	0.5392
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2299	1	1
Echinococcus multilocularis	protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	growth factor receptor bound protein 2	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2299	1	1
Echinococcus granulosus	expressed conserved protein	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	STAT protein	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK/Met protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.0923	0.3652	0.3133
Echinococcus granulosus	SH2 domain containing protein 7	0.1376	0.574	0.5392
Schistosoma mansoni	suppressor of cytokine signaling	0.1376	0.574	0.5392
Echinococcus granulosus	c src tyrosine kinase	0.2299	1	1
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	SHC transforming protein 3	0.1376	0.574	0.5392
Brugia malayi	hypothetical protein	0.1376	0.574	0.5392
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0923	0.3652	0.3133
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0923	0.3652	0.3133
Entamoeba histolytica	serine/threonine kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	Sex muscle abnormal protein 5	0.1376	0.574	0.5392
Schistosoma mansoni	protein tyrosine kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	protein kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.2299	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Onchocerca volvulus		0.1376	0.574	0.329
Echinococcus multilocularis		0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0923	0.3652	0.3133
Echinococcus granulosus	hypothetical protein	0.1376	0.574	0.5392
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1376	0.574	0.5392
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0923	0.3652	0.3133
Plasmodium falciparum	protein kinase, putative	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0923	0.3652	0.3133
Brugia malayi	Raf kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	hypothetical protein	0.0923	0.3652	0.3133
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0923	0.3652	0.3133
Echinococcus multilocularis	protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1376	0.574	0.5392
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Schistosoma mansoni	tensin	0.1376	0.574	0.5392
Trypanosoma cruzi	protein kinase, putative	0.0923	0.3652	1
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Loa Loa (eye worm)	TK protein kinase	0.2299	1	1
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0923	0.3652	0.3133
Trichomonas vaginalis	STE family protein kinase	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	tyrosine kinase	0.2299	1	1
Loa Loa (eye worm)	SRC-1	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0923	0.3652	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0923	0.3652	0.3133
Onchocerca volvulus		0.1376	0.574	0.329
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0923	0.3652	0.3133
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Brugia malayi	Variant SH3 domain containing protein	0.1376	0.574	0.5392
Loa Loa (eye worm)	TK/INSR protein kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	hypothetical protein	0.1376	0.574	0.5392
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Brugia malayi	SRC-1	0.2299	1	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0923	0.3652	1
Entamoeba histolytica	cysteine surface protein, putative	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK protein kinase	0.0923	0.3652	0.3133
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2299	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0923	0.3652	0.3133
Plasmodium falciparum	protein kinase, putative	0.0923	0.3652	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Echinococcus granulosus	signal transduction protein lnk realted	0.1376	0.574	0.5392
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0923	0.3652	0.3133
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0923	0.3652	0.3133
Echinococcus granulosus	natriuretic peptide receptor 1	0.0923	0.3652	0.3133
Entamoeba histolytica	tyrosin kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	hypothetical protein	0.2299	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0923	0.3652	0.3133
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2299	1	1
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0923	0.3652	0.3133
Trypanosoma brucei	Pseudokinase, putative	0.0923	0.3652	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0923	0.3652	0.3133
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1376	0.574	0.5392
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Toxoplasma gondii	protein kinase	0.0923	0.3652	1
Echinococcus multilocularis	tensin	0.1376	0.574	0.5392
Trichomonas vaginalis	conserved hypothetical protein	0.0923	0.3652	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	SH2 domain containing protein	0.1376	0.574	0.5392
Echinococcus granulosus	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	activated cdc42 kinase 1	0.0923	0.3652	0.3133
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0923	0.3652	0.3133
Echinococcus granulosus	SHC transforming protein 3	0.1376	0.574	0.5392
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0923	0.3652	0.3133
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2299	1	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0923	0.3652	0.5
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Echinococcus multilocularis	activin receptor type	0.0923	0.3652	0.3133
Echinococcus multilocularis	activated cdc42 kinase 1	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	hypothetical protein	0.1376	0.574	0.5392
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase, putative	0.1376	0.574	0.574
Echinococcus granulosus	N chimaerin	0.1376	0.574	0.5392
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	tyrosine kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0923	0.3652	0.3133
Echinococcus granulosus	epidermal growth factor receptor	0.0923	0.3652	0.3133
Brugia malayi	Protein kinase domain containing protein	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1376	0.574	0.5392
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0923	0.3652	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0923	0.3652	0.3133
Brugia malayi	integrin-linked kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/FER protein kinase	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2299	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1376	0.574	0.5392
Schistosoma mansoni	ephrin receptor	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	tyrosine kinase, putative	0.0923	0.3652	0.3652
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2299	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0923	0.3652	0.3652
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Entamoeba histolytica	serine/threonine kinase, putative	0.0923	0.3652	0.3652
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0923	0.3652	0.3133
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0923	0.3652	0.5
Entamoeba histolytica	protein kinase, putative	0.0923	0.3652	0.3652
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0296	0.0756	0.2071
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1376	0.574	0.5392
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Brugia malayi	protein-tyrosine kinase	0.2299	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0923	0.3652	0.3133
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2299	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Schistosoma mansoni	protein kinase	0.0923	0.3652	0.3133
Loa Loa (eye worm)	TK/ROR protein kinase	0.0923	0.3652	0.3133
Entamoeba histolytica	protein kinase domain containing protein	0.0923	0.3652	0.3652
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1376	0.574	0.5392
Schistosoma mansoni	growth factor receptor-bound protein	0.1376	0.574	0.5392
Schistosoma mansoni	SH2A	0.1376	0.574	0.5392
Entamoeba histolytica	hypothetical protein	0.0923	0.3652	0.3652
Schistosoma mansoni	tyrosine kinase	0.2299	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0923	0.3652	0.3133
Loa Loa (eye worm)	hypothetical protein	0.0923	0.3652	0.3133
Trichomonas vaginalis	TKL family protein kinase	0.0923	0.3652	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1376	0.574	0.5392
Plasmodium falciparum	tyrosine kinase-like protein	0.0923	0.3652	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2134444

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1712052