Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0048 | 0.3736 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0048 | 0.3736 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0048 | 0.3736 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | ecdysteroid receptor | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0048 | 0.3736 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0048 | 0.3736 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | nuclear hormone receptor | 0.0048 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | nuclear hormone receptor | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0048 | 0.3736 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | thyroid hormone receptor | 0.0048 | 0.3736 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0048 | 0.3736 | 0.3736 |
Onchocerca volvulus | 0.0048 | 0.3736 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0048 | 0.3736 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | FTZ F1 alpha | 0.0048 | 0.3736 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0048 | 0.3736 | 0.3736 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0048 | 0.3736 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0048 | 0.3736 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0048 | 0.3736 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0048 | 0.3736 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0048 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0048 | 0.3736 | 0.3736 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0048 | 0.3736 | 0.3736 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0048 | 0.3736 | 0.3736 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0048 | 0.3736 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0048 | 0.3736 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3736 | 0.3736 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0048 | 0.3736 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0048 | 0.3736 | 0.3736 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0048 | 0.3736 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.