Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1523 | 0.2612 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.5828 | 0.5828 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1523 | 0.2612 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.5828 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1523 | 0.2612 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.5828 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.5828 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1523 | 0.2612 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.5828 | 1 |
Schistosoma mansoni | kinase | 0.0058 | 0.1344 | 0.1344 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2825 | 0.4847 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5828 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2825 | 0.4847 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.5828 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2825 | 0.2825 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.5828 | 0.4186 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.5828 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.5828 | 0.4186 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.5828 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2825 | 0.4847 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3188 | 0.5469 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2825 | 0.4847 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.5828 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2825 | 0.4847 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.5828 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2825 | 0.4847 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.