Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1712 | 0.325 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.4671 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0052 | 0.3253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5267 | 0.5267 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.5267 | 0.5267 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.011 | 0.8331 | 0.8331 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.5267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.8331 | 0.8331 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0039 | 0.2089 | 1 |
Onchocerca volvulus | 0.0052 | 0.3253 | 1 | |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.1712 | 0.1712 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.1712 | 0.1712 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0039 | 0.2089 | 0.6421 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.3253 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4671 | 0.8869 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.4671 | 0.4671 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.4671 | 0.4671 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1712 | 0.3664 |
Brugia malayi | RNA binding protein | 0.0068 | 0.4671 | 0.4671 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.1712 | 0.1712 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1712 | 0.325 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1712 | 0.325 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.3253 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.3253 | 0.3253 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.4671 | 0.4671 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.3253 | 0.3253 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1712 | 0.1712 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3253 | 0.3253 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0052 | 0.3253 | 1 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.1712 | 0.3664 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.011 | 0.8331 | 0.8331 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0052 | 0.3253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2089 | 0.2089 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0039 | 0.2089 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.3253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2089 | 0.2089 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.1901 | 0.5844 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0052 | 0.3253 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4671 | 0.8869 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.1712 | 0.3664 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.3253 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4671 | 0.8869 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4671 | 0.8869 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3253 | 0.3253 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.011 | 0.8331 | 0.8331 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.4671 | 0.4671 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.1901 | 0.5844 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0052 | 0.3253 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0052 | 0.3253 | 1 |
Toxoplasma gondii | propionate-CoA ligase | 0.0015 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0052 | 0.3253 | 0.3253 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0039 | 0.2089 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2089 | 0.2089 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.4671 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0015 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.3253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3253 | 0.3253 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.1901 | 0.5844 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1712 | 0.3664 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.3253 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2089 | 0.2089 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1712 | 0.3664 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.4671 | 0.8869 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1712 | 0.3664 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0037 | 0.1901 | 0.5844 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0052 | 0.3253 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0052 | 0.3253 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0039 | 0.2089 | 0.6421 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0052 | 0.3253 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1712 | 0.325 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.4671 | 0.4671 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0052 | 0.3253 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.3253 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2089 | 0.2089 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0052 | 0.3253 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 30.6379 uM | PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.