Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1274 | 0.2697 |
Onchocerca volvulus | 0.0037 | 0.1274 | 0.5 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.1274 | 0.5088 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1274 | 0.2697 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2504 | 0.5301 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1274 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.1274 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2058 | 0.4357 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.1274 | 0.2697 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1274 | 0.2697 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2504 | 0.5301 |
Onchocerca volvulus | 0.0037 | 0.1274 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2058 | 0.8221 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1274 | 0.2697 |
Brugia malayi | beta-lactamase | 0.0037 | 0.1274 | 0.2697 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2058 | 0.8221 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1274 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2504 | 0.5301 |
Onchocerca volvulus | 0.0037 | 0.1274 | 0.5 | |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.1274 | 0.2697 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2504 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.1274 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2058 | 0.8221 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.1274 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2504 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2504 | 0.5301 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1274 | 0.5088 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.1274 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2058 | 0.8221 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1274 | 0.2697 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1274 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.1274 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2504 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2504 | 0.5301 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.1274 | 0.5088 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2504 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.1274 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.1274 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.1274 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1274 | 0.2697 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1274 | 0.5088 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1274 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2504 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1274 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1274 | 0.2697 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1274 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.1274 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2058 | 0.8221 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2058 | 0.8221 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.1274 | 0.2697 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2058 | 0.4357 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2504 | 0.5301 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1274 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2504 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2504 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4723 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.1274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1274 | 0.2697 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.1274 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4723 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2058 | 0.8221 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.