Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3521 | 0.3392 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3887 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.3887 | 0.3887 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3887 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0738 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.014 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.3887 | 0.3765 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1982 | 0.1822 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.8515 | 0.8515 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3521 | 0.3521 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0738 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.3887 | 0.3765 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0738 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.014 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0738 | 0.0553 |
Loa Loa (eye worm) | lipase | 0.014 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.8515 | 0.8485 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0738 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3887 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.3887 | 0.3765 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0738 | 0.0738 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0196 | 0.0196 |
Trichomonas vaginalis | lipase containing protein, putative | 0.014 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.014 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.014 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1982 | 0.4839 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.8515 | 0.8485 |
Onchocerca volvulus | 0.014 | 1 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3887 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.014 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3521 | 0.3521 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.3887 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.014 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.3887 | 0.3887 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.3887 | 0.3765 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1982 | 0.1982 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.3887 | 0.3765 |
Brugia malayi | RNA binding protein | 0.0065 | 0.3887 | 0.3887 |
Trypanosoma brucei | lipase domain protein, putative | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3521 | 0.3392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.