Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0821 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0821 | 0.0573 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2278 | 0.2068 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0264 | 0.0859 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0294 | 0.003 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0821 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1346 | 0.4376 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0821 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0264 | 0.0859 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3075 | 0.2887 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3075 | 0.2887 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2278 | 0.2068 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0264 | 0.0859 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0264 | 0.0859 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1346 | 0.1111 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2278 | 0.2068 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0264 | 0.0859 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3075 | 0.2887 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3075 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0264 | 0.0859 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3075 | 0.2887 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0821 | 0.0573 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0821 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0264 | 0.0859 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0821 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0821 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1346 | 0.1111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2278 | 0.2068 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0821 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0821 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3075 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3075 | 0.2887 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.