Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.4451 | 0.9312 |
Schistosoma mansoni | phosphatidylserine receptor | 0.0015 | 0.0655 | 0.0655 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0014 | 0.0531 | 0.0262 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0017 | 0.0819 | 0.0649 |
Schistosoma mansoni | lamin | 0.0026 | 0.165 | 0.165 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.093 | 0.1267 |
Echinococcus multilocularis | lamin | 0.0026 | 0.165 | 0.2926 |
Loa Loa (eye worm) | histone methyltransferase | 0.0017 | 0.0839 | 0.1059 |
Schistosoma mansoni | phd/f-box containing protein | 0.0015 | 0.0655 | 0.0655 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0019 | 0.0943 | 0.121 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.093 | 0.093 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.093 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0056 | 0.4331 | 0.4331 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.093 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0655 | 0.0258 |
Echinococcus multilocularis | jumonji domain containing 1A | 0.0015 | 0.0655 | 0.0558 |
Echinococcus granulosus | lamin | 0.0026 | 0.165 | 0.2845 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0655 | 0.0637 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.093 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.165 | 0.2926 |
Schistosoma mansoni | jumonji domain containing protein | 0.0015 | 0.0655 | 0.0655 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.093 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.093 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.165 | 0.165 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.4451 | 0.9598 |
Schistosoma mansoni | lamin | 0.0026 | 0.165 | 0.165 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.093 | 0.0913 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.093 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.4739 | 0.4739 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.093 | 0.1179 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.093 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0017 | 0.0839 | 0.0996 |
Echinococcus granulosus | JmjC domain containing protein 4 | 0.0015 | 0.0655 | 0.0542 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0061 | 0.4739 | 1 |
Echinococcus multilocularis | phd:f box containing protein | 0.0015 | 0.0655 | 0.0558 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.093 | 0.093 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.093 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.006 | 0.4619 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.165 | 0.2845 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0547 | 0.0389 |
Brugia malayi | jmjC domain containing protein | 0.0061 | 0.4739 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0014 | 0.0531 | 0.0255 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.093 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.093 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0017 | 0.0839 | 0.0969 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.165 | 0.263 |
Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.0015 | 0.0655 | 0.0655 |
Echinococcus granulosus | jumonji domain containing 1A | 0.0015 | 0.0655 | 0.0542 |
Brugia malayi | CXXC zinc finger family protein | 0.0056 | 0.4331 | 0.9027 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.4451 | 0.4451 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0655 | 0.0637 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.165 | 0.2845 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.4451 | 0.9598 |
Schistosoma mansoni | protein phosphatase 2C | 0.0015 | 0.0655 | 0.0655 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0655 | 0.0637 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0107 | 0.8854 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.093 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.165 | 0.2917 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.093 | 0.1212 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0019 | 0.0943 | 0.1244 |
Echinococcus granulosus | phd:f box containing protein | 0.0015 | 0.0655 | 0.0542 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0056 | 0.4331 | 0.9065 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1606 | 0.2817 |
Echinococcus multilocularis | lysine specific demethylase 6a | 0.0015 | 0.0655 | 0.0558 |
Onchocerca volvulus | 0.0056 | 0.4331 | 1 | |
Echinococcus multilocularis | JmjC domain containing protein 4 | 0.0015 | 0.0655 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0655 | 0.0637 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0014 | 0.0531 | 0.0255 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0655 | 0.0258 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.165 | 0.263 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.165 | 0.2917 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.4619 | 0.4619 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.4739 | 1 |
Echinococcus granulosus | cpg binding protein | 0.006 | 0.4619 | 0.9723 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0061 | 0.4739 | 0.4739 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.4619 | 0.4619 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.093 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0655 | 0.0258 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.165 | 0.2917 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.093 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0015 | 0.0655 | 0.0258 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0015 | 0.0655 | 0.0637 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0014 | 0.0531 | 0.0531 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.4451 | 0.9332 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.093 | 0.0335 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0655 | 0.0637 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0014 | 0.0531 | 0.0262 |
Echinococcus multilocularis | musashi | 0.0026 | 0.165 | 0.2926 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0421 | 0.01 |
Echinococcus granulosus | lysine specific demethylase 6a | 0.0015 | 0.0655 | 0.0542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.