Detailed information for compound 1713378

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 489.568 | Formula: C30H27N5O2
  • H donors: 0 H acceptors: 3 LogP: 5.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nn2c(c1)nc(cc2N1CCN(CC1)C(=O)c1ccccc1)c1ccccc1
  • InChi: 1S/C30H27N5O2/c1-37-25-14-12-23(13-15-25)27-20-28-31-26(22-8-4-2-5-9-22)21-29(35(28)32-27)33-16-18-34(19-17-33)30(36)24-10-6-3-7-11-24/h2-15,20-21H,16-19H2,1H3
  • InChiKey: ATOGEGSDNGEMHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0569 0.0569
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.759 0.745
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0569 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0569 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0569 0.0569
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 0.0569 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.6856 0.6666
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0569 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6856 0.6666
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0569 0.5
Loa Loa (eye worm) TAR-binding protein 0.0076 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.6856 0.6856
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4772 0.4469
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.6856 0.6856
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0569 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0569 0.0569
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.1503 0.1503
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0569 0.0022
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0569 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Loa Loa (eye worm) hypothetical protein 0.006 0.759 0.745
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0569 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0569 0.0569
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0569 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0569 0.0569
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0569 0.5
Brugia malayi Latrophilin receptor protein 2 0.0019 0.1503 0.099
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0569 1
Schistosoma mansoni hypothetical protein 0.0019 0.1503 0.099
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.1503 0.099
Echinococcus multilocularis GPCR, family 2 0.0019 0.1503 0.1503
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.6856 0.6856
Leishmania major p-glycoprotein 0.0013 0.0569 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.4772 0.4457
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6856 0.6666
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0569 0.0569
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.1503 0.1503
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0569 0.0569
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0569 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0569 0.0569
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 0.0569 1
Onchocerca volvulus 0.0013 0.0569 0.5
Loa Loa (eye worm) RNA binding protein 0.0076 1 1
Echinococcus granulosus tar DNA binding protein 0.0076 1 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0569 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0569 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0569 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6856 0.6666
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.1503 0.101
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.759 0.7444
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.759 0.7444
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 0.0569 1
Brugia malayi TAR-binding protein 0.0076 1 1
Echinococcus multilocularis tar DNA binding protein 0.0076 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0569 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.1503 0.101
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0569 0.5
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0569 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0569 0.5
Trichomonas vaginalis abcb9, putative 0.0013 0.0569 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0569 0.0569
Loa Loa (eye worm) hypothetical protein 0.0013 0.0569 0.0022
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Trichomonas vaginalis taga, putative 0.0013 0.0569 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0569 0.0022
Schistosoma mansoni hypothetical protein 0.0041 0.4772 0.4457
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0569 0.0569
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0569 0.0569
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0569 0.0569
Schistosoma mansoni tar DNA-binding protein 0.0076 1 1
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0569 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.1503 0.1503
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0569 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0569 0.0569
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 0.0569 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.1503 0.1503
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Echinococcus granulosus GPCR family 2 0.0019 0.1503 0.1503
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.6856 0.6673
Trichomonas vaginalis abcb9, putative 0.0013 0.0569 1
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0569 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0076 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 0.0569 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0548 0.0548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.6856 0.6856
Trichomonas vaginalis ABC transporter, putative 0.0013 0.0569 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0548 0.0548
Schistosoma mansoni hypothetical protein 0.0019 0.1503 0.099
Schistosoma mansoni hypothetical protein 0.0019 0.1503 0.099
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 0.0569 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0569 0.0569
Trichomonas vaginalis abcb9, putative 0.0013 0.0569 1
Schistosoma mansoni hypothetical protein 0.0019 0.1503 0.099

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 0.69 uM PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen. Follow-up assay for Set 2. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) 0.72 uM PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen. Follow-up assay on set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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