Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0164 | 0.0146 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0164 | 0.0146 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0164 | 0.0499 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3285 | 0.3273 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Schistosoma mansoni | ras GTP exchange factor | 0.0008 | 0.0018 | 0.0054 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3285 | 1 |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0164 | 0.0447 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3285 | 0.3273 |
Onchocerca volvulus | 0.0011 | 0.0164 | 0.0146 | |
Schistosoma mansoni | ras GTP exchange factor son of sevenless | 0.0008 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0164 | 0.0146 |
Schistosoma mansoni | guanine-nucleotide-exchange-factor | 0.0008 | 0.0018 | 0.0054 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3285 | 0.3273 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0164 | 0.5 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0164 | 0.0146 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0164 | 0.0447 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0164 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0164 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0164 | 0.0499 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0164 | 0.0447 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0.0018 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0.0018 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3285 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3285 | 0.3273 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0164 | 0.0499 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0164 | 0.0499 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.4368 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.