Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.0233 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0038 | 0.0233 | 0.0233 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.2582 |
Brugia malayi | TAR-binding protein | 0.0049 | 0.0441 | 0.1431 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0024 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0024 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0072 | 0.0896 | 0.0896 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0219 | 0.071 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0158 | 0.2582 | 1 |
Brugia malayi | hypothetical protein | 0.0183 | 0.3081 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.8379 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0158 | 0.2582 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0183 | 0.3081 | 0.3081 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0514 | 0.0514 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0158 | 0.2582 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0024 | 0.0076 |
Brugia malayi | isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.8379 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0077 | 0.0995 | 0.323 |
Onchocerca volvulus | 0.0037 | 0.021 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0514 | 0.1669 |
Loa Loa (eye worm) | RNA binding protein | 0.0049 | 0.0441 | 0.1431 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0158 | 0.2582 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.0441 | 0.0441 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0534 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0024 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.0233 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.2582 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0031 | 0.0079 | 0.0079 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0158 | 0.2582 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0158 | 0.2582 | 0.2582 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.021 | 0.021 |
Brugia malayi | jmjC domain containing protein | 0.0072 | 0.0896 | 0.2908 |
Echinococcus multilocularis | tar DNA binding protein | 0.0049 | 0.0441 | 0.0441 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0038 | 0.0233 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.0441 | 0.0441 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3081 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0077 | 0.0995 | 0.323 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0158 | 0.2582 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0158 | 0.2582 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.2582 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0028 | 0.0024 | 0.0024 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.2582 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.2582 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0028 | 0.0024 | 0.0024 |
Schistosoma mansoni | survival motor neuron protein | 0.0037 | 0.021 | 0.021 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.0233 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.0441 | 0.0441 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0038 | 0.0233 | 0.0233 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0534 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0038 | 0.0233 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0049 | 0.0441 | 0.1431 |
Loa Loa (eye worm) | TAR-binding protein | 0.0049 | 0.0441 | 0.1431 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0038 | 0.0233 | 0.0757 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0183 | 0.3081 | 0.3081 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0037 | 0.021 | 0.0683 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0158 | 0.2582 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.0441 | 0.0441 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.0604 | 0.0604 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.8379 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0072 | 0.0896 | 0.0896 |
Brugia malayi | RNA binding protein | 0.0049 | 0.0441 | 0.1431 |
Echinococcus granulosus | tar DNA binding protein | 0.0049 | 0.0441 | 0.0441 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0024 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0049 | 0.0441 | 0.1431 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0995 | 0.323 |
Brugia malayi | MAP kinase sur-1 | 0.0038 | 0.0233 | 0.0757 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0038 | 0.0233 | 0.0233 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0158 | 0.2582 | 0.2582 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0158 | 0.2582 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0031 | 0.0079 | 0.0079 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0028 | 0.0024 | 0.0024 |
Schistosoma mansoni | tar DNA-binding protein | 0.0049 | 0.0441 | 0.0441 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0158 | 0.2582 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0038 | 0.0233 | 0.0233 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0053 | 0.0514 | 0.1669 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0045 | 0.0371 | 0.1203 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0077 | 0.0995 | 0.323 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0038 | 0.0233 | 0.0233 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 3.1 | Inhibition of acetic acid induced writhing in mice at dose of 3.12 mg/kg | ChEMBL. | 9873678 |
Inhibition (functional) | = 12.1 % | Inhibition of acetic acid induced writhing in mice at dose of 1.56 mg/kg | ChEMBL. | 9873678 |
Inhibition (functional) | = 12.1 % | Inhibition of acetic acid induced writhing in mice at dose of 1.56 mg/kg | ChEMBL. | 9873678 |
Inhibition (functional) | = 76.5 % | Inhibition of acetic acid induced writhing in mice at dose of 3.12 mg/kg | ChEMBL. | 9873678 |
Inhibition (functional) | = 76.5 % | Inhibition of acetic acid induced writhing in mice at dose of 3.12 mg/kg | ChEMBL. | 9873678 |
Inhibition (functional) | = 80.5 % | Inhibition of acetic acid induced writhing in mice at dose of 6.25 mg/kg | ChEMBL. | 9873678 |
Inhibition (functional) | = 80.5 % | Inhibition of acetic acid induced writhing in mice at dose of 6.25 mg/kg | ChEMBL. | 9873678 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.