Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0059 | 0.079 | 0.079 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.049 | 1 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.049 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.049 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.049 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0059 | 0.079 | 0.079 |
Onchocerca volvulus | Putative nachr subunit | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.049 | 1 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0059 | 0.079 | 0.079 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0059 | 0.079 | 0.079 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0059 | 0.079 | 0.079 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.049 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0059 | 0.079 | 0.079 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0059 | 0.079 | 0.079 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.049 | 1 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.049 | 1 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.049 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.049 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.049 | 1 | 0.5 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0059 | 0.079 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.049 | 1 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0059 | 0.079 | 0.079 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0059 | 0.079 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.049 | 1 | 0.5 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0059 | 0.079 | 0.079 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.079 | 0.079 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0059 | 0.079 | 0.079 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0059 | 0.079 | 0.079 |
Brugia malayi | Isocitrate dehydrogenase | 0.049 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.049 | 1 | 0.5 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0059 | 0.079 | 0.5 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0059 | 0.079 | 0.079 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0059 | 0.079 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.049 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.049 | 1 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0059 | 0.079 | 0.079 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0059 | 0.079 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.049 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.049 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 2230 nM | In vitro binding affinity by inhibiting [3H]-Cytisine binding in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 12086489 |
Ki (binding) | = 2230 nM | In vitro binding affinity by inhibiting [3H]-Cytisine binding in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 12086489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.