Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cholecystokinin A receptor | Starlite/ChEMBL | No references |
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0133 | 0.4771 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0133 | 0.4771 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0133 | 0.4771 | 0.4771 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0133 | 0.4771 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0133 | 0.4771 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0133 | 0.4771 | 0.4771 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0133 | 0.4771 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0133 | 0.4771 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0133 | 0.4771 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1474 | 0.1474 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0133 | 0.4771 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0133 | 0.4771 | 0.4771 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1474 | 0.1474 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0133 | 0.4771 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0792 | 0.0792 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0133 | 0.4771 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1474 | 0.1474 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0133 | 0.4771 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0261 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0133 | 0.4771 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0133 | 0.4771 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.4483 | 0.4483 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0133 | 0.4771 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0133 | 0.4771 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0133 | 0.4771 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1474 | 0.1474 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.4483 | 0.4483 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.4483 | 0.4483 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0133 | 0.4771 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0792 | 0.0792 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0792 | 0.166 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2200 nM | Inhibitory activity towards binding of [125I]-Bolton-Hunter-CCK-8 to CCKA receptor in guinea pig pancreatic tissue | ChEMBL. | No reference |
IC50 (binding) | = 2200 nM | Inhibitory activity towards binding of [125I]-Bolton-Hunter-CCK-8 to CCKA receptor in guinea pig pancreatic tissue | ChEMBL. | No reference |
IC50 (binding) | = 3900 nM | Inhibitory activity towards binding of [125I]-Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue | ChEMBL. | No reference |
IC50 (binding) | = 3900 nM | Inhibitory activity towards binding of [125I]-Bolton-Hunter-CCK-8 to CCKB receptor in guinea pig cortical tissue | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.