Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5507 | 0.5507 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3559 | 0.3559 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 1 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5507 | 0.5507 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1281 | 0.1281 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3559 | 0.3559 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5507 | 0.4847 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5507 | 0.4847 |
Schistosoma mansoni | kinase | 0.0058 | 0.3292 | 0.2307 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5507 | 0.5507 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5507 | 0.4847 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5507 | 0.4847 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5507 | 0.5507 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5507 | 0.4847 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3559 | 0.3559 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1281 | 0.1281 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5507 | 0.5507 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5507 | 0.5507 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3559 | 0.3559 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.9173 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.