Detailed information for compound 1714719

Basic information

Technical information
  • TDR Targets ID: 1714719
  • Name: 3-[(1-cyclopentyltetrazol-5-yl)-(4-ethylpiper azin-1-yl)methyl]-6-methyl-1H-quinolin-2-one
  • MW: 421.539 | Formula: C23H31N7O
  • H donors: 1 H acceptors: 4 LogP: 2.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)C(c1cc2cc(C)ccc2[nH]c1=O)c1nnnn1C1CCCC1
  • InChi: 1S/C23H31N7O/c1-3-28-10-12-29(13-11-28)21(22-25-26-27-30(22)18-6-4-5-7-18)19-15-17-14-16(2)8-9-20(17)24-23(19)31/h8-9,14-15,18,21H,3-7,10-13H2,1-2H3,(H,24,31)
  • InChiKey: UWVHRMUCWCGYDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1-cyclopentyl-5-tetrazolyl)-(4-ethyl-1-piperazinyl)methyl]-6-methyl-1H-quinolin-2-one
  • 3-[(1-cyclopentyltetrazol-5-yl)-(4-ethylpiperazin-1-yl)methyl]-6-methyl-carbostyril
  • 3-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-(4-ethylpiperazin-1-yl)methyl]-6-methyl-1H-quinolin-2-one
  • Oprea1_691321
  • ASN 03775140

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi tubulin alpha-2 chain 0.0191 0.2031 0.2643
Echinococcus multilocularis tubulin beta 1 chain 0.0252 0.2749 0.2749
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0254 0.0299
Trypanosoma brucei alpha tubulin, putative 0.0077 0.0705 0.2564
Entamoeba histolytica hypothetical protein 0.0039 0.0254 0.0582
Echinococcus multilocularis Tubulin alpha 1 chain 0.0191 0.2031 0.2031
Trypanosoma cruzi tubulin delta chain 0.0059 0.0495 0.18
Trichomonas vaginalis tubulin beta chain, putative 0.0191 0.2031 0.7027
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0426 0.1549
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0333 0.0392
Trichomonas vaginalis tubulin beta chain, putative 0.0252 0.2749 1
Echinococcus granulosus expressed conserved protein 0.0099 0.0964 0.1137
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Schistosoma mansoni tubulin subunit beta 0.0252 0.2749 0.3241
Leishmania major epsilon tubulin, putative 0.0137 0.1398 0.5087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0099 0.2011
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0226 0.2451 0.8916
Loa Loa (eye worm) hypothetical protein 0.0054 0.0428 0.0558
Plasmodium falciparum peptidase, putative 0.0053 0.0426 0.1549
Echinococcus granulosus tubulin alpha chain 0.0191 0.2031 0.2394
Trypanosoma brucei beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0191 0.2031 0.2031
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.0129
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0024 0.0088
Trichomonas vaginalis tubulin alpha chain, putative 0.0137 0.1398 0.441
Trichomonas vaginalis tubulin beta chain, putative 0.0077 0.0705 0.154
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0059 0.0495 0.18
Echinococcus granulosus Tubulin beta 2C chain 0.0252 0.2749 0.3241
Toxoplasma gondii beta-tubulin, putative 0.0252 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0333 0.0433
Leishmania major beta tubulin 0.0252 0.2749 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0226 0.2451 0.289
Trypanosoma brucei zeta tubulin 0.0059 0.0495 0.18
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0099 0.0362
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0099 0.0362
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1303 0.1696
Echinococcus granulosus Tubulin beta 2C chain 0.0252 0.2749 0.3241
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0053 0.0426 0.1549
Schistosoma mansoni hypothetical protein 0.0044 0.0314 0.037
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0137 0.1398 0.5087
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0674 0.7682 0.9058
Schistosoma mansoni hypothetical protein 0.0037 0.023 0.0271
Giardia lamblia Alpha-tubulin 0.0191 0.2031 0.6908
Entamoeba histolytica tubulin family protein 0.0252 0.2749 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0377 0.0444
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0053 0.0426 0.0502
Trichomonas vaginalis tubulin gamma chain, putative 0.0252 0.2749 1
Brugia malayi prolyl oligopeptidase family protein 0.0053 0.0426 0.0554
Schistosoma mansoni tubulin subunit alpha 0.0059 0.0495 0.0583
Schistosoma mansoni lamin 0.0029 0.014 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0012 0.0241
Onchocerca volvulus 0.0077 0.0705 0.0798
Echinococcus multilocularis tubulin alpha chain 0.0191 0.2031 0.2031
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0426 0.0386
Schistosoma mansoni tubulin subunit beta 0.0252 0.2749 0.3241
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0059 0.0495 0.18
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0053 0.0426 0.0386
Onchocerca volvulus 0.0052 0.0408 0.0407
Loa Loa (eye worm) beta-tubulin 0.0252 0.2749 0.3578
Leishmania major gamma-tubulin 0.0137 0.1398 0.5087
Trypanosoma cruzi tubulin gamma chain 0.0137 0.1398 0.5087
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0053 0.0426 0.0502
Mycobacterium tuberculosis Cell division protein FtsZ 0.0059 0.0495 1
Echinococcus granulosus tubulin alpha 1C chain 0.0191 0.2031 0.2394
Trichomonas vaginalis tubulin, putative 0.0252 0.2749 1
Toxoplasma gondii prolyl endopeptidase 0.0053 0.0426 0.1549
Echinococcus multilocularis expressed conserved protein 0.0099 0.0964 0.0964
Leishmania major beta tubulin 0.0252 0.2749 1
Plasmodium falciparum alpha tubulin 1 0.0191 0.2031 0.7387
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.014 0.0183
Trypanosoma cruzi epsilon tubulin, putative 0.0137 0.1398 0.5087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0129
Leishmania major beta tubulin 0.0252 0.2749 1
Brugia malayi hypothetical protein 0.0039 0.0254 0.033
Echinococcus granulosus beta tubulin 0.0252 0.2749 0.3241
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0674 0.7682 0.9058
Loa Loa (eye worm) alpha-tubulin 0.0191 0.2031 0.2643
Brugia malayi beta-tubulin, identical 0.0252 0.2749 0.3578
Plasmodium vivax delta tubulin, putative 0.0059 0.0495 0.18
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0254 0.0254
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0674 0.7682 0.7682
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0031
Loa Loa (eye worm) tubulin gamma chain 0.0137 0.1398 0.182
Echinococcus granulosus prolyl endopeptidase 0.0053 0.0426 0.0502
Echinococcus multilocularis Tubulin alpha 1 chain 0.0191 0.2031 0.2031
Brugia malayi Cell division protein ftsZ 0.0059 0.0495 0.0644
Trichomonas vaginalis tubulin alpha chain, putative 0.0252 0.2749 1
Echinococcus multilocularis tubulin alpha chain 0.0191 0.2031 0.2031
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0113 0.1127 0.3288
Echinococcus multilocularis protein patched 0.0045 0.0333 0.0333
Echinococcus multilocularis tubulin alpha 3 chain 0.0191 0.2031 0.2031
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0333 0.0333
Plasmodium falciparum alpha tubulin 2 0.0191 0.2031 0.7387
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0226 0.2451 0.8916
Loa Loa (eye worm) hypothetical protein 0.0254 0.2775 0.3613
Brugia malayi Tubulin alpha chain 0.0191 0.2031 0.2643
Loa Loa (eye worm) hypothetical protein 0.0037 0.023 0.0299
Trypanosoma cruzi epsilon tubulin, putative 0.0137 0.1398 0.5087
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.2714 0.3533
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0175
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0012 0.0241
Trichomonas vaginalis tubulin, putative 0.0059 0.0495 0.067
Entamoeba histolytica tubulin family protein 0.0252 0.2749 1
Giardia lamblia Alpha-tubulin 0.0191 0.2031 0.6908
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0024 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0191 0.2031 0.7027
Echinococcus granulosus Tubulin alpha 1 chain 0.0191 0.2031 0.2394
Giardia lamblia Beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0151 0.1571 0.1571
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0129
Echinococcus multilocularis musashi 0.0029 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0056 0.0452 0.0589
Loa Loa (eye worm) tubulin alpha-3 chain 0.0113 0.1127 0.1467
Trichomonas vaginalis tubulin gamma chain, putative 0.0137 0.1398 0.441
Trypanosoma cruzi zeta tubulin, putative 0.0059 0.0495 0.18
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0053 0.0426 0.0502
Loa Loa (eye worm) tubulin beta chain 0.0059 0.0495 0.0644
Echinococcus granulosus tubulin alpha 3 chain 0.0191 0.2031 0.2394
Trypanosoma brucei prolyl oligopeptidase, putative 0.0053 0.0426 0.1549
Echinococcus granulosus tubulin subunit TubB 0.0191 0.2031 0.2394
Loa Loa (eye worm) hypothetical protein 0.0191 0.2031 0.2643
Echinococcus multilocularis tubulin delta chain 0.0059 0.0495 0.0495
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.104 0.3548
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0183
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0333 0.0433
Trypanosoma cruzi prolyl endopeptidase 0.0053 0.0426 0.1549
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.1059 0.1248
Trichomonas vaginalis tubulin epsilon chain, putative 0.0191 0.2031 0.7027
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0705 0.154
Echinococcus multilocularis microtubule associated protein 2 0.0742 0.848 0.848
Trypanosoma brucei beta tubulin 0.0137 0.1398 0.5087
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0053 0.0426 0.1549
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.104 0.1353
Loa Loa (eye worm) tubulin beta-4 chain 0.0252 0.2749 0.3578
Echinococcus granulosus tubulin gamma 1 chain 0.0137 0.1398 0.1649
Trypanosoma brucei tubulin delta chain 0.0059 0.0495 0.18
Trypanosoma brucei oligopeptidase b 0.0053 0.0426 0.1549
Leishmania major beta tubulin 0.0252 0.2749 1
Schistosoma mansoni hypothetical protein 0.0039 0.0254 0.0299
Trichomonas vaginalis tubulin, putative 0.0077 0.0705 0.154
Trypanosoma cruzi alpha tubulin, putative 0.0191 0.2031 0.7387
Trichomonas vaginalis tubulin beta chain, putative 0.0191 0.2031 0.7027
Echinococcus granulosus tubulin alpha 1C chain 0.0191 0.2031 0.2394
Schistosoma mansoni tubulin subunit beta 0.0252 0.2749 0.3241
Brugia malayi alpha-tubulin 0.0191 0.2031 0.2643
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0705 0.154
Plasmodium vivax tubulin alpha chain, putative 0.0191 0.2031 0.7387
Loa Loa (eye worm) alpha-tubulin 0.0191 0.2031 0.2643
Loa Loa (eye worm) hypothetical protein 0.0053 0.0423 0.0551
Entamoeba histolytica tubulin alpha-1 chain 0.0191 0.2031 0.7289
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.023 0.0299
Echinococcus multilocularis Tubulin beta 2C chain 0.0252 0.2749 0.2749
Trypanosoma brucei zeta tubulin, putative 0.0059 0.0495 0.18
Echinococcus granulosus tubulin beta 4A class IVa 0.0252 0.2749 0.3241
Schistosoma mansoni patched 1 0.0045 0.0333 0.0392
Echinococcus granulosus Tubulin alpha 1 chain 0.0191 0.2031 0.2394
Plasmodium falciparum tubulin gamma chain 0.0137 0.1398 0.5087
Brugia malayi MH2 domain containing protein 0.0128 0.1303 0.1696
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0099 0.1602
Loa Loa (eye worm) tubulin beta chain 0.0252 0.2749 0.3578
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus granulosus tubulin alpha chain 0.0191 0.2031 0.2394
Giardia lamblia Delta tubulin 0.0059 0.0495 0.0296
Echinococcus granulosus acylamino acid releasing enzyme 0.0053 0.0426 0.0502
Echinococcus granulosus tubulin beta 1 chain 0.0252 0.2749 0.3241
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0053 0.0426 0.826
Brugia malayi Tubulin beta chain 0.0059 0.0495 0.0644
Giardia lamblia Beta tubulin 0.0252 0.2749 1
Echinococcus granulosus Tubulin beta 2C chain 0.0252 0.2749 0.3241
Trypanosoma brucei beta tubulin 0.0252 0.2749 1
Brugia malayi Tubulin alpha chain 0.0059 0.0495 0.0644
Schistosoma mansoni alpha tubulin 0.0191 0.2031 0.2394
Echinococcus granulosus Tubulin alpha 1 chain 0.0191 0.2031 0.2394
Echinococcus granulosus tubulin alpha chain 0.0191 0.2031 0.2394
Entamoeba histolytica hypothetical protein, conserved 0.0053 0.0426 0.1232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0426 0.0554
Echinococcus granulosus Tubulin beta 2C chain 0.0252 0.2749 0.3241
Schistosoma mansoni hypothetical protein 0.0182 0.1932 0.2279
Echinococcus multilocularis lamin 0.0029 0.014 0.014
Loa Loa (eye worm) tubulin alpha chain 0.0191 0.2031 0.2643
Schistosoma mansoni tubulin subunit beta 0.0059 0.0495 0.0583
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Brugia malayi Tubulin alpha-2 chain 0.0191 0.2031 0.2643
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0226 0.2451 0.2451
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0012 0.0241
Echinococcus multilocularis lamin dm0 0.0029 0.014 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0426 0.1549
Trichomonas vaginalis tubulin beta chain, putative 0.0191 0.2031 0.7027
Schistosoma mansoni microtubule-associated protein tau 0.0742 0.848 1
Toxoplasma gondii alpha-tubulin I, putative 0.0191 0.2031 0.7387
Brugia malayi Tubulin alpha-2 chain 0.0191 0.2031 0.2643
Leishmania major beta tubulin 0.0252 0.2749 1
Brugia malayi CHE-14 protein 0.0045 0.0333 0.0433
Echinococcus multilocularis tubulin alpha 1C chain 0.0191 0.2031 0.2031
Onchocerca volvulus 0.0029 0.014 0.0054
Giardia lamblia Beta tubulin 0.0252 0.2749 1
Onchocerca volvulus Huntingtin homolog 0.0132 0.1342 0.1639
Trypanosoma brucei alpha tubulin 0.0191 0.2031 0.7387
Mycobacterium ulcerans hypothetical protein 0.0025 0.0099 0.1602
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus granulosus tumor protein p63 0.0363 0.4051 0.4777
Echinococcus multilocularis tubulin alpha chain 0.0191 0.2031 0.2031
Leishmania major beta tubulin 0.0252 0.2749 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0137 0.1398 0.5087
Schistosoma mansoni hypothetical protein 0.0182 0.1932 0.2279
Onchocerca volvulus 0.0029 0.014 0.0054
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0053 0.0426 0.1549
Onchocerca volvulus Prolyl endopeptidase homolog 0.0053 0.0426 0.043
Echinococcus granulosus survival motor neuron protein 1 0.0254 0.2775 0.3273
Schistosoma mansoni tubulin subunit beta 0.0252 0.2749 0.3241
Trichomonas vaginalis tubulin gamma chain, putative 0.0137 0.1398 0.441
Leishmania major beta tubulin 0.0252 0.2749 1
Brugia malayi prolyl oligopeptidase family protein 0.0674 0.7682 1
Giardia lamblia Gamma tubulin 0.0137 0.1398 0.4186
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Echinococcus granulosus Niemann Pick C1 protein 0.0151 0.1571 0.1852
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0053 0.0426 0.8539
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0226 0.2451 0.8916
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0226 0.2451 0.8916
Trichomonas vaginalis tubulin beta chain, putative 0.0191 0.2031 0.7027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0031
Leishmania major zeta tubulin, putative 0.0059 0.0495 0.18
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0031
Trypanosoma brucei alpha tubulin 0.0191 0.2031 0.7387
Echinococcus multilocularis tubulin alpha 3 chain 0.0191 0.2031 0.2031
Schistosoma mansoni tubulin subunit delta 0.0059 0.0495 0.0583
Schistosoma mansoni tubulin subunit gamma 0.0137 0.1398 0.1649
Schistosoma mansoni hypothetical protein 0.0044 0.0314 0.037
Echinococcus granulosus tubulin alpha chain 0.0191 0.2031 0.2394
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0191 0.2031 0.7027
Mycobacterium tuberculosis Probable peptidase 0.0053 0.0426 0.861
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0226 0.2451 0.8916
Brugia malayi Tubulin gamma chain 0.0137 0.1398 0.182
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0077 0.0705 0.154
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0099 0.1602
Schistosoma mansoni alpha tubulin 0.0191 0.2031 0.2394
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0377 0.0377
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0099 0.1602
Leishmania major delta tubulin, putative 0.0059 0.0495 0.18
Leishmania major beta tubulin 0.0252 0.2749 1
Trypanosoma cruzi tubulin delta chain 0.0059 0.0495 0.18
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0012 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0099 0.1602
Trichomonas vaginalis tubulin epsilon chain, putative 0.0191 0.2031 0.7027
Plasmodium falciparum tubulin beta chain 0.0252 0.2749 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0099 0.0362
Brugia malayi tubulin alpha chain - mouse 0.0191 0.2031 0.2643
Loa Loa (eye worm) tubulin beta-1 chain 0.0252 0.2749 0.3578
Toxoplasma gondii beta-1 tubulin, putative 0.0252 0.2749 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0252 0.2749 0.2749
Loa Loa (eye worm) hypothetical protein 0.0132 0.1342 0.1747
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0377 0.049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0377 0.0444
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0226 0.2451 0.8916
Echinococcus granulosus beta tubulin 0.0252 0.2749 0.3241
Brugia malayi hypothetical protein 0.0132 0.1342 0.1747
Entamoeba histolytica hypothetical protein 0.0039 0.0254 0.0582
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.104 0.1226
Trichomonas vaginalis tubulin epsilon chain, putative 0.0059 0.0495 0.067
Echinococcus granulosus lamin 0.0029 0.014 0.0166
Mycobacterium ulcerans cell division protein FtsZ 0.0059 0.0495 1
Echinococcus multilocularis tumor protein p63 0.0363 0.4051 0.4051
Loa Loa (eye worm) BEN-1 protein 0.0252 0.2749 0.3578
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Trypanosoma cruzi oligopeptidase b 0.0053 0.0426 0.1549
Brugia malayi prolyl oligopeptidase family protein 0.0226 0.2451 0.319
Entamoeba histolytica prolyl oligopeptidase family protein 0.0053 0.0426 0.1232
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0674 0.7682 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0053 0.0426 0.861
Plasmodium vivax tubulin gamma chain, putative 0.0137 0.1398 0.5087
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0495 0.067
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0053 0.0426 0.1549
Loa Loa (eye worm) tubulin alpha-2 chain 0.0191 0.2031 0.2643
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0099 0.1602
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0031
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Trypanosoma cruzi zeta tubulin, putative 0.0059 0.0495 0.18
Echinococcus granulosus geminin 0.0182 0.1932 0.2279
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0426 0.1549
Entamoeba histolytica hypothetical protein 0.0039 0.0254 0.0582
Trypanosoma cruzi beta tubulin, putative 0.0252 0.2749 1
Echinococcus granulosus lamin dm0 0.0029 0.014 0.0166
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0053 0.0426 0.0502
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1337 0.1741
Schistosoma mansoni intermediate filament proteins 0.0029 0.014 0.0166
Brugia malayi Tubulin beta chain 0.0077 0.0705 0.0918
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Echinococcus granulosus tubulin delta chain 0.0059 0.0495 0.0583
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.014 0.0183
Onchocerca volvulus Huntingtin homolog 0.0132 0.1342 0.1639
Toxoplasma gondii hypothetical protein 0.0053 0.0426 0.1549
Brugia malayi prolyl oligopeptidase family protein 0.0053 0.0426 0.0554
Entamoeba histolytica tubulin gamma chain 0.0137 0.1398 0.4902
Echinococcus granulosus peroxisome assembly protein 26 0.0191 0.2031 0.2394
Echinococcus multilocularis Tubulin beta 2C chain 0.0252 0.2749 0.2749
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0059 0.0495 0.5
Echinococcus granulosus alpha tubulin 0.0191 0.2031 0.2394
Echinococcus granulosus tubulin epsilon chain 0.0137 0.1398 0.1649
Brugia malayi hypothetical protein 0.0254 0.2775 0.3613
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.0129
Echinococcus granulosus tubulin alpha 3 chain 0.0191 0.2031 0.2394
Leishmania major beta tubulin 0.0252 0.2749 1
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0053 0.0426 0.1549
Echinococcus multilocularis Tubulin beta 2C chain 0.0252 0.2749 0.2749
Loa Loa (eye worm) tubulin alpha 2 0.0054 0.0434 0.0565
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0099 0.2011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0428 0.0558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0377 0.0444
Echinococcus granulosus intermediate filament protein 0.0029 0.014 0.0166
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0377 0.049
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0099 0.1602
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0129
Echinococcus granulosus microtubule associated protein 2 0.0742 0.848 1
Trypanosoma brucei epsilon tubulin 0.0137 0.1398 0.5087
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0137 0.1398 0.1398
Brugia malayi follicle stimulating hormone receptor 0.0249 0.2714 0.3533
Echinococcus multilocularis geminin 0.0182 0.1932 0.1932
Trypanosoma brucei epsilon tubulin 0.0137 0.1398 0.5087
Echinococcus multilocularis peroxisome assembly protein 26 0.0191 0.2031 0.2031
Schistosoma mansoni lamin 0.0029 0.014 0.0166
Echinococcus multilocularis tubulin subunit beta 0.0252 0.2749 0.2749
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0333 0.0392
Echinococcus granulosus tubulin subunit beta 0.0252 0.2749 0.3241
Echinococcus multilocularis beta tubulin 0.0252 0.2749 0.2749
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0377 0.0444
Loa Loa (eye worm) hypothetical protein 0.0113 0.1127 0.1467
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0053 0.0426 0.1232
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0252 0.2749 0.2749
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0053 0.0426 0.1549
Trypanosoma brucei alpha tubulin 0.0191 0.2031 0.7387
Trichomonas vaginalis tubulin epsilon chain, putative 0.0252 0.2749 1
Loa Loa (eye worm) tubulin alpha chain 0.0191 0.2031 0.2643
Loa Loa (eye worm) hypothetical protein 0.0132 0.1342 0.1747
Leishmania major oligopeptidase b 0.0053 0.0426 0.1549
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0495 0.067
Onchocerca volvulus 0.0053 0.0423 0.0427
Schistosoma mansoni alpha tubulin 0.0191 0.2031 0.2394
Loa Loa (eye worm) BEN-1 protein 0.0252 0.2749 0.3578
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0131 0.1337 0.1741
Plasmodium vivax tubulin alpha chain, putative 0.0191 0.2031 0.7387
Entamoeba histolytica hypothetical protein 0.0039 0.0254 0.0582
Loa Loa (eye worm) hypothetical protein 0.0053 0.0426 0.0554
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.0129
Echinococcus multilocularis prolyl endopeptidase 0.0053 0.0426 0.0426
Trichomonas vaginalis tubulin beta chain, putative 0.0191 0.2031 0.7027
Trichomonas vaginalis tubulin epsilon chain, putative 0.0252 0.2749 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0131 0.1337 0.4158
Entamoeba histolytica prolyl oligopeptidase family protein 0.0053 0.0426 0.1232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0377 0.0444
Trypanosoma brucei beta tubulin 0.0252 0.2749 1
Trypanosoma brucei prolyl endopeptidase 0.0053 0.0426 0.1549
Leishmania major beta tubulin 0.0252 0.2749 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0053 0.0426 0.0386
Giardia lamblia Epsilon tubulin 0.0059 0.0495 0.0296
Echinococcus granulosus Dipeptidyl peptidase 9 0.0226 0.2451 0.289
Loa Loa (eye worm) hypothetical protein 0.0131 0.1337 0.1741
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0053 0.0426 0.1549
Loa Loa (eye worm) hypothetical protein 0.0053 0.0426 0.0554
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0428 0.0558
Echinococcus multilocularis protein dispatched 1 0.0052 0.0408 0.0408
Schistosoma mansoni hypothetical protein 0.0044 0.0314 0.037
Loa Loa (eye worm) tubulin alpha 2 0.0131 0.1337 0.1741
Echinococcus multilocularis acylamino acid releasing enzyme 0.0053 0.0426 0.0426
Toxoplasma gondii alpha tubulin TUBA1 0.0191 0.2031 0.7387
Echinococcus multilocularis hypothetical protein 0.0191 0.2031 0.2031
Echinococcus granulosus tubulin alpha 0.0137 0.1398 0.1649
Schistosoma mansoni tubulin subunit alpha 0.0191 0.2031 0.2394
Loa Loa (eye worm) hypothetical protein 0.0106 0.104 0.1353
Entamoeba histolytica tubulin alpha chain, putative 0.0191 0.2031 0.7289
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0024 0.0088
Schistosoma mansoni hypothetical protein 0.0044 0.0314 0.037
Echinococcus granulosus Tubulin beta 2C chain 0.0252 0.2749 0.3241
Echinococcus multilocularis tubulin epsilon chain 0.0137 0.1398 0.1398
Trypanosoma brucei epsilon tubulin 0.0137 0.1398 0.5087
Echinococcus multilocularis beta tubulin 0.0252 0.2749 0.2749
Loa Loa (eye worm) prolyl oligopeptidase 0.0674 0.7682 1
Plasmodium vivax tubulin beta chain, putative 0.0252 0.2749 1
Echinococcus multilocularis survival motor neuron protein 1 0.0254 0.2775 0.2775
Echinococcus multilocularis tubulin alpha 0.0137 0.1398 0.1398
Trypanosoma brucei alpha tubulin 0.0191 0.2031 0.7387
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0254 0.0299
Plasmodium vivax tubulin epsilon chain, putative 0.0137 0.1398 0.5087
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0024 0.0487
Brugia malayi prolyl oligopeptidase family protein 0.0053 0.0426 0.0554
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0053 0.0426 0.1232
Treponema pallidum cell division protein FtsZ 0.0059 0.0495 0.5
Brugia malayi Tubulin beta-1 chain 0.0252 0.2749 0.3578
Schistosoma mansoni tubulin subunit alpha 0.0191 0.2031 0.2394
Echinococcus multilocularis tubulin alpha chain 0.0191 0.2031 0.2031
Loa Loa (eye worm) tubulin beta-2A chain 0.0252 0.2749 0.3578
Brugia malayi intermediate filament protein 0.0029 0.014 0.0183
Leishmania major beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis tubulin alpha chain 0.0191 0.2031 0.2031
Plasmodium falciparum tubulin delta chain, putative 0.0059 0.0495 0.18
Mycobacterium leprae cell division protein FtsZ 0.0059 0.0495 1
Echinococcus granulosus tubulin alpha chain 0.0191 0.2031 0.2394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0377 0.0377
Toxoplasma gondii beta tubulin 0.0252 0.2749 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0099 0.1602
Trypanosoma brucei beta tubulin 0.0252 0.2749 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0191 0.2031 0.2031
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.104 0.104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0428 0.0558
Schistosoma mansoni tubulin subunit beta 0.0252 0.2749 0.3241
Trypanosoma brucei tubulin gamma chain 0.0137 0.1398 0.5087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0031
Schistosoma mansoni hypothetical protein 0.0052 0.0408 0.0481
Schistosoma mansoni tubulin subunit alpha 0.0191 0.2031 0.2394
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1303 0.1696
Trypanosoma cruzi oligopeptidase b 0.0053 0.0426 0.1549
Loa Loa (eye worm) prolyl oligopeptidase 0.0053 0.0426 0.0554
Entamoeba histolytica prolyl oligopeptidase family protein 0.0053 0.0426 0.1232
Echinococcus multilocularis tubulin subunit TubB 0.0191 0.2031 0.2031
Schistosoma mansoni tubulin subunit epsilon 0.0137 0.1398 0.1649
Schistosoma mansoni tubulin subunit beta 0.0252 0.2749 0.3241
Schistosoma mansoni survival motor neuron protein 0.0052 0.0408 0.0481
Loa Loa (eye worm) intermediate filament protein 0.0029 0.014 0.0183
Trichomonas vaginalis tubulin, putative 0.0077 0.0705 0.154
Leishmania major beta tubulin 0.0252 0.2749 1
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0423 0.0499
Trichomonas vaginalis tubulin alpha chain, putative 0.0077 0.0705 0.154
Trichomonas vaginalis tubulin gamma chain, putative 0.0059 0.0495 0.067
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0059 0.0495 0.067
Leishmania major alpha tubulin 0.0191 0.2031 0.7387
Loa Loa (eye worm) hypothetical protein 0.0173 0.1826 0.2377
Brugia malayi hypothetical protein 0.0173 0.1826 0.2377
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0408 0.0531
Echinococcus multilocularis Tubulin beta 2C chain 0.0252 0.2749 0.2749

Activities

Activity type Activity value Assay description Source Reference
FC (binding) Inhibition of LYP-mediated TCR signaling in C305 antibody stimulated mouse Ptpn22+/+ T cells assessed as increase in Src Y416 phosphorylation at 50 uM by Western blotting relative to untreated control ChEMBL. 21341673
IC50 (binding) > 40 uM Inhibition of LYP expressed in Escherichia coli BL21 using pNPP substrate ChEMBL. 21341673

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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