Detailed information for compound 171473

Basic information

Technical information
  • TDR Targets ID: 171473
  • Name: (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(1H-imid azol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl )propanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol -3-yl)-1-oxopropan-2-yl]-5-(diaminomethyliden eamino)pentanamide
  • MW: 701.775 | Formula: C34H43N11O6
  • H donors: 10 H acceptors: 7 LogP: 0.02 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)[C@H](Cc1[nH]cnc1)NC(=O)C)Cc1ccc(cc1)O
  • InChi: 1S/C34H43N11O6/c1-19(46)42-29(15-22-17-38-18-41-22)33(51)45-28(13-20-8-10-23(47)11-9-20)32(50)43-26(7-4-12-39-34(36)37)31(49)44-27(30(35)48)14-21-16-40-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,40,47H,4,7,12-15H2,1H3,(H2,35,48)(H,38,41)(H,42,46)(H,43,50)(H,44,49)(H,45,51)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1
  • InChiKey: FGCBZBMPOFJXID-FKWFRFQNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-5-guanidino-pentanamide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)-1-oxopropyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-N-[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]-5-guanidinopentanamide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-azanyl-3-(1H-indol-3-yl)-1-oxo-propan-2-yl]-5-[bis(azanyl)methylideneamino]pentanamide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-keto-ethyl]-5-guanidino-valeramide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-5-guanidino-pentanamide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(3H-imidazol-4-yl)-1-oxopropyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-N-[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]-5-guanidinopentanamide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-keto-ethyl]-5-guanidino-valeramide
  • (2S)-2-[[(2R)-2-[[(2S)-2-acetamido-3-(3H-imidazol-4-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxo-propan-2-yl]-5-(diaminomethylideneamino)pentanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus melanocortin 3 receptor Starlite/ChEMBL References
Mus musculus melanocortin 5 receptor Starlite/ChEMBL References
Mus musculus melanocortin 1 receptor Starlite/ChEMBL References
Mus musculus melanocortin 4 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein melanocortin 5 receptor 372 aa 314 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0211 0.0197
Brugia malayi Cathepsin L-like precursor 0.0019 0.006 0.0045
Schistosoma mansoni cpg binding protein 0.0029 0.0162 0.0148
Brugia malayi excitatory GABA receptor EXP-1A 0.0115 0.1064 0.1051
Brugia malayi Nuclear hormone receptor E75 0.0036 0.0239 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0211 0.0197
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0053 0.0418 0.0404
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0118 0.1096 0.1082
Schistosoma mansoni survival motor neuron protein 0.0043 0.031 0.0295
Echinococcus granulosus glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0062 0.0511 0.0497
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0194 0.018
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0019 0.0004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0028 0.0157 0.0157
Plasmodium vivax sugar transporter, putative 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Leishmania major cathepsin L-like protease 0.0107 0.0977 0.096
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4107 0.4098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0206 0.0966
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0124 0.0109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Brugia malayi hypothetical protein 0.0032 0.0197 0.0182
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0249 0.023
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0054 0.0428 0.0428
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0124 0.0109
Echinococcus granulosus glycine receptor subunit beta 0.0115 0.1064 0.1051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0076 0.0658 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0974 1 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0359 0.0345
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Onchocerca volvulus 0.0019 0.006 0.0331
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0157 0.0718
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Schistosoma mansoni hypothetical protein 0.0408 0.4107 0.4098
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Leishmania major isocitrate dehydrogenase, putative 0.0118 0.1096 0.1079
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.0157 0.0157
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Plasmodium vivax vivapain-2 0.0028 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni zinc finger protein 0.0036 0.0239 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0076 0.0658 0.0658
Schistosoma mansoni cpg binding protein 0.003 0.0179 0.0165
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.1036 0.1023
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Echinococcus multilocularis nAChR subunit 0.0062 0.0511 0.0497
Onchocerca volvulus 0.0062 0.0511 0.3973
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0974 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0036 0.0239 0.0224
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Echinococcus granulosus FTZ F1 alpha 0.0076 0.0658 0.0644
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0118 0.1096 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0974 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0974 1 1
Brugia malayi Cation transporter family protein 0.0115 0.1064 0.1051
Onchocerca volvulus 0.0043 0.031 0.2347
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0194 0.135
Loa Loa (eye worm) hypothetical protein 0.0279 0.2772 0.2772
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0118 0.1096 0.1096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0113 0.1036 0.1023
Loa Loa (eye worm) cysteine protease 0.0028 0.0157 0.0157
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0076 0.0658 0.0658
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0974 1 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.1036 0.1023
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0115 0.1064 0.1064
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0359 0.0345
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0062 0.0511 0.0497
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Loa Loa (eye worm) nuclear hormone receptor 0.0036 0.0239 0.0239
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0194 0.018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0974 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.0239 0.1775
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0053 0.0418 0.0404
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0211 0.0197
Onchocerca volvulus 0.0115 0.1064 0.8444
Brugia malayi hypothetical protein 0.0016 0.0032 0.0017
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0115 0.1064 0.1051
Giardia lamblia Kinase, CMGC CK2 0.0142 0.1344 1
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0262 0.0247
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0115 0.1064 0.1051
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0977 0.0964
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Onchocerca volvulus 0.0053 0.0418 0.3222
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Onchocerca volvulus 0.0115 0.1064 0.8444
Loa Loa (eye worm) hypothetical protein 0.0033 0.0211 0.0211
Schistosoma mansoni coup transcription factor 0.0076 0.0658 0.0644
Brugia malayi hypothetical protein 0.0015 0.0019 0.0004
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.011 0.0095
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.0157 0.0142
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0206 0.0191
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0124 0.0109
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni glucose transport protein 0.0106 0.0964 0.095
Entamoeba histolytica tartrate dehydrogenase, putative 0.0118 0.1096 0.8134
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0036 0.0239 0.0239
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0197 0.0182
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0019 0.0004
Echinococcus granulosus casein kinase ii subunit beta 0.0038 0.0262 0.0247
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0239 0.0224
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0418 0.0404
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.011 0.0091
Onchocerca volvulus 0.0028 0.0157 0.1111
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0157 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Toxoplasma gondii isocitrate dehydrogenase 0.0974 1 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.1651 0.1638
Brugia malayi nuclear hormone receptor family member odr-7 0.0036 0.0239 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0964 0.4812
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0239 0.0224
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0211 0.0211
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0115 0.1064 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus nuclear receptor nhr 48 0.0036 0.0239 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Toxoplasma gondii CMGC kinase, CK2 family 0.0142 0.1344 0.1327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0076 0.0658 0.0644
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0284 0.0269
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.011 0.0095
Loa Loa (eye worm) sugar transporter 0.0106 0.0964 0.0964
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0211 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0076 0.0658 0.0658
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0262 0.0247
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0239 0.0224
Echinococcus multilocularis nAChR subunit 0.0115 0.1064 0.1051
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0115 0.1064 0.1064
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0194 0.018
Echinococcus multilocularis cpg binding protein 0.003 0.0179 0.0165
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0076 0.0658 0.0644
Plasmodium falciparum protein kinase 6 0.0449 0.454 0.4531
Loa Loa (eye worm) hypothetical protein 0.0025 0.0124 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Loa Loa (eye worm) isocitrate dehydrogenase 0.0974 1 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0249 0.0234
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0428 0.0413
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0157 0.1111
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.004 0.0284 0.0269
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0115 0.1064 0.1051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.006
Leishmania major protein kinase, putative 0.0033 0.0211 0.0192
Schistosoma mansoni nuclear hormone receptor 0.0076 0.0658 0.0644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0429 0.0411
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Schistosoma mansoni nuclear receptor nhr-48 0.0036 0.0239 0.0224
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0053 0.0418 0.0418
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0053 0.0418 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0249 0.0234
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0036 0.0239 0.0224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0206 0.0191
Trypanosoma brucei RNA helicase, putative 0.0335 0.3347 0.3337
Brugia malayi Csnk2b protein 0.0038 0.0262 0.0247
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Onchocerca volvulus 0.0048 0.0359 0.2748
Schistosoma mansoni RAR-like nuclear receptor 0.0076 0.0658 0.0644
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0076 0.0658 0.516
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.011 0.0685
Brugia malayi conserved hypotetical protein 0.0036 0.0239 0.0224
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0226 0.2219 0.2219
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Brugia malayi Sugar transporter family protein 0.0015 0.0019 0.0004
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0115 0.1064 0.1064
Echinococcus granulosus General substrate transporter 0.0091 0.0809 0.0795
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0019 0.0019
Onchocerca volvulus 0.0115 0.1064 0.8444
Loa Loa (eye worm) Csnk2b protein 0.0038 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi nuclear hormone receptor 0.0076 0.0658 0.0644
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0249 0.0234
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0974 1 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Giardia lamblia Casein kinase II beta chain 0.0038 0.0262 0.1832
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0428 0.0413
Leishmania major hypothetical protein, conserved 0.0025 0.0124 0.0105
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0051 0.0036
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0118 0.1096 0.1082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0076 0.0658 0.0644
Schistosoma mansoni hypothetical protein 0.0043 0.031 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0076 0.0658 0.0644
Brugia malayi nuclear receptor NHR-88 0.0076 0.0658 0.0644
Onchocerca volvulus 0.0036 0.0239 0.1775
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0428 0.0413
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0262 0.0247
Schistosoma mansoni thyroid hormone receptor 0.0076 0.0658 0.0644
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0359 0.0345
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0038 0.0262 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0115 0.1064 0.1051
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0115 0.1064 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Nuclear hormone receptor E75 0.0036 0.0239 0.0224
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.011
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0197 0.0182
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0019 0.0004
Echinococcus multilocularis casein kinase ii subunit alpha 0.0142 0.1344 0.1331
Brugia malayi Isocitrate dehydrogenase 0.0974 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0118 0.1096 0.1082
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi Nuclear hormone receptor-like 1 0.0076 0.0658 0.0644
Brugia malayi Sugar transporter family protein 0.0015 0.0019 0.0004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0036 0.0239 0.0224
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.011 0.0095
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0157 0.0142
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.011 0.0843
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.0157 0.0142
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.0157 0.0142
Brugia malayi Probable isocitrate dehydrogenase 0.0118 0.1096 0.1082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0115 0.1064 0.1051
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Entamoeba histolytica protein kinase domain containing protein 0.0142 0.1344 1
Brugia malayi hypothetical protein 0.0036 0.0239 0.0224
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0076 0.0658 0.0644
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0511 0.0497
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0076 0.0658 0.0644
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0211 0.0193
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0359 0.0345
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0262 0.1857
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0974 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0115 0.1064 0.1051
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0098 0.0881 0.0867
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0194 0.0909
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0977 0.0964
Entamoeba histolytica cysteine protease, putative 0.0028 0.0157 0.1066
Schistosoma mansoni protein kinase 0.0033 0.0211 0.0196
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis FTZ F1 alpha 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0019 0.006 0.006
Brugia malayi Cam kinase protein 1 0.0033 0.0211 0.0196
Entamoeba histolytica hypothetical protein 0.0062 0.0511 0.3732
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.006 0.0339
Trypanosoma cruzi hexose transporter 0.0033 0.0206 0.0191
Loa Loa (eye worm) ACC-1 protein 0.0115 0.1064 0.1064
Brugia malayi tailless protein 0.0036 0.0239 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.008 0.0328
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0162 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0118 0.1096 0.1082
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0211 0.0197
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.011 0.0095
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0115 0.1064 0.1051
Schistosoma mansoni glucose transport protein 0.0106 0.0964 0.095
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1814 0.1802
Onchocerca volvulus 0.0049 0.0378 0.2895
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0038 0.0262 0.0243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0076 0.0658 0.0644
Brugia malayi hypothetical protein 0.0036 0.0239 0.0224
Echinococcus multilocularis nuclear receptor nhr 48 0.0036 0.0239 0.0224
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0124 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0076 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0425 0.429 0.429
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0076 0.0658 0.0644
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0194 0.018
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0428 0.0413
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0076 0.0658 0.0644
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0115 0.1064 0.1051
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0496 0.0482
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0974 1 1
Plasmodium falciparum protein kinase 7 0.0299 0.298 0.2969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Brugia malayi nuclear receptor RXR 0.004 0.0284 0.0269
Leishmania major glucose transporter, lmgt2 0.0033 0.0206 0.0187
Plasmodium vivax hexose transporter 0.0106 0.0964 0.095
Brugia malayi hypothetical protein 0.004 0.0284 0.0269
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Onchocerca volvulus 0.0053 0.0418 0.3222
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0118 0.1096 0.1082
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0194 0.1187
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0249 0.023
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi hypothetical protein 0.0015 0.0019 0.0004
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0019 0.0004
Brugia malayi Cation transporter family protein 0.0115 0.1064 0.1051
Schistosoma mansoni neurotransmitter gated ion channel 0.0053 0.0418 0.0404
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0115 0.1064 0.1051
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0157 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.1036 0.9448
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0115 0.1064 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0157 0.1066
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.004 0.0284 0.0284
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4107 0.4098
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 0.1036 0.1019
Brugia malayi major facilitator superfamily protein 0.0015 0.0019 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.0076 0.0658 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0076 0.0658 0.0644
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0038 0.0262 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0124 0.0109
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0428 0.0413
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.006 0.0045
Trypanosoma cruzi cysteine peptidase, putative 0.0107 0.0977 0.0964
Leishmania major glucose transporter, lmgt3 0.0033 0.0206 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0076 0.0658 0.0658
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0053 0.0418 0.0418
Brugia malayi Sugar transporter family protein 0.0106 0.0964 0.095
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0974 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0115 0.1064 0.1064
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0053 0.0418 0.0404
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0239 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0076 0.0658 0.0644
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0073 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi mbt repeat family protein 0.0048 0.0359 0.0345
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0359 0.0345
Echinococcus granulosus cathepsin l1 0.0019 0.006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Plasmodium vivax unspecified product 0.0142 0.1344 0.1331
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0211 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0211 0.0995
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0053 0.0418 0.0404
Echinococcus granulosus glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Echinococcus multilocularis survival motor neuron protein 1 0.021 0.2046 0.2034
Brugia malayi nuclear hormone receptor family member nhr-6 0.0036 0.0239 0.0224
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.011 0.0362
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0036 0.0239 0.0224
Onchocerca volvulus Cathepsin F homolog 0.0028 0.0157 0.1111
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0157 0.0142
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0118 0.1096 0.1079
Schistosoma mansoni hypothetical protein 0.0289 0.2872 0.2861
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0076 0.0658 0.0644
Onchocerca volvulus 0.0028 0.0157 0.1111
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0019 0.0004
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0206 0.0966
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni nuclear receptor 0.0036 0.0239 0.0224
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0197 0.0182
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Echinococcus granulosus nAChR subunit 0.0062 0.0511 0.0497
Leishmania major cathepsin L-like protease 0.0107 0.0977 0.096
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0036 0.0239 0.0224
Plasmodium vivax casein kinase II beta chain, putative 0.0038 0.0262 0.0247
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0249 0.0234
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0249 0.0234
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.1036 0.1019
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.0964 0.0946
Echinococcus multilocularis cysteine protease 0.0028 0.0157 0.0142
Brugia malayi nuclear receptor NHR-67 0.0036 0.0239 0.0224
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0142 0.1344 0.1331
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Brugia malayi Steroid receptor seven-up type 2 0.0076 0.0658 0.0644
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0211 0.0197
Brugia malayi Cation transporter family protein 0.0115 0.1064 0.1051
Onchocerca volvulus 0.0028 0.0157 0.1111
Echinococcus granulosus thyroid hormone receptor alpha 0.0036 0.0239 0.0224
Echinococcus multilocularis isocitrate dehydrogenase 0.0974 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Brugia malayi photoreceptor-specific nuclear receptor 0.0076 0.0658 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0076 0.0658 0.0644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Loa Loa (eye worm) hypothetical protein 0.0049 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0206 0.0966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0076 0.0658 0.0644
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Brugia malayi lysyl-tRNA synthetase 0.0024 0.011 0.0095
Loa Loa (eye worm) ctsf protein 0.0028 0.0157 0.0157
Loa Loa (eye worm) sugar transporter 0.0015 0.0019 0.0019
Loa Loa (eye worm) MBCTL1 0.0054 0.0428 0.0428
Trypanosoma cruzi casein kinase II, putative 0.0142 0.1344 0.1331
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0359 0.0345
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0076 0.0658 0.0644
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0211 0.0193
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Echinococcus granulosus cpg binding protein 0.003 0.0179 0.0165
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0157 0.0157
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0204 0.1987 0.1975
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0115 0.1064 0.1051
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Onchocerca volvulus 0.0028 0.0157 0.1111
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0076 0.0658 0.0658
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0974 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0036 0.0239 0.0224
Schistosoma mansoni neurotransmitter gated ion channel 0.0062 0.0511 0.0497
Brugia malayi Cathepsin L-like precursor 0.0019 0.006 0.0045
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.0157 0.0142
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0974 1 1
Entamoeba histolytica hypothetical protein 0.0032 0.0197 0.1366
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0428 0.0413
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0284 0.0269
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0115 0.1064 0.1051
Brugia malayi hypothetical protein 0.004 0.0284 0.0269
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Brugia malayi nuclear hormone receptor 0.0036 0.0239 0.0224
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0118 0.1096 0.1082
Entamoeba histolytica casein kinase, putative 0.0142 0.1344 1
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0118 0.1096 0.1082
Leishmania major cathepsin L-like protease 0.0107 0.0977 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0157 0.0718
Onchocerca volvulus Glucosylceramidase homolog 0.0134 0.1257 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.011 0.0095
Brugia malayi hypothetical protein 0.0015 0.0019 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0076 0.0658 0.0644
Schistosoma mansoni steroid hormone receptor ad4bp 0.0076 0.0658 0.0644
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.1332 0.6679
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.011 0.0481
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0115 0.1064 0.1051
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0249 0.023
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0206 0.0966
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Brugia malayi ecdysone receptor 0.0036 0.0239 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0021
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0157 0.1111
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0038 0.0262 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0262 0.1857
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0076 0.0658 0.0644
Echinococcus multilocularis glycine receptor subunit beta 0.0115 0.1064 0.1051
Onchocerca volvulus 0.0036 0.0239 0.1775
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trypanosoma brucei sugar transporter, putative 0.0015 0.0019 0.0004
Echinococcus multilocularis General substrate transporter 0.0091 0.0809 0.0795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.011 0.0095
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0211 0.0193
Plasmodium falciparum casein kinase 2, alpha subunit 0.0142 0.1344 0.1331
Loa Loa (eye worm) GABA receptor subunit 0.0062 0.0511 0.0511
Onchocerca volvulus Putative nachr subunit 0.0115 0.1064 0.8444
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Onchocerca volvulus 0.0053 0.0418 0.3222
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Schistosoma mansoni acetylcholine receptor-related 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Plasmodium falciparum casein kinase II beta chain 0.0038 0.0262 0.0247
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.1332 0.6679
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0359 0.0359
Onchocerca volvulus Bile acid receptor homolog 0.0076 0.0658 0.516
Toxoplasma gondii protein kinase, putative 0.0299 0.298 0.2966
Loa Loa (eye worm) DR-78 0.0036 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.0964 0.095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.1036 0.1023
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0115 0.1064 0.1051
Echinococcus granulosus nAChR subunit 0.0115 0.1064 0.1051
Brugia malayi CXXC zinc finger family protein 0.0029 0.0162 0.0148
Plasmodium vivax CDK-related protein kinase 6, putative 0.0449 0.454 0.4531
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Schistosoma mansoni casein kinase II beta subunit 0.0038 0.0262 0.0247
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.006 0.0229
Brugia malayi steroid hormone receptor 0.0076 0.0658 0.0644
Trypanosoma cruzi major cysteine proteinase, putative 0.0084 0.0739 0.0725
Loa Loa (eye worm) LGC-31 protein 0.0115 0.1064 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0206 0.0966
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.004 0.0284 0.0269
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0019 0.0004
Echinococcus multilocularis cysteine protease 0.0028 0.0157 0.0142
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0242 0.2377 0.2366
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0019 0.0004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0335 0.3347 0.3337
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0206 0.0187
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0026 0.0133 0.0133
Brugia malayi Probable isocitrate dehydrogenase 0.0118 0.1096 0.1082
Brugia malayi Cathepsin L-like precursor 0.0028 0.0157 0.0142
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0194 0.1887 0.1887
Onchocerca volvulus 0.0029 0.0162 0.1158
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0279 0.2772 0.2761
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0115 0.1064 0.1051
Brugia malayi cathepsin L-like precursor 0.0019 0.006 0.0045
Onchocerca volvulus 0.0028 0.0157 0.1111
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0974 1 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0105 0.0957 0.0957
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0076 0.0658 0.0644
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0157 0.1066
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0157 0.0142
Echinococcus granulosus casein kinase ii subunit alpha 0.0142 0.1344 0.1331
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0211 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0076 0.0658 0.0644
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Schistosoma mansoni cpg binding protein 0.003 0.0179 0.0165
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0115 0.1064 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.1651 0.1635
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0201 0.1958 0.1946
Echinococcus granulosus cathepsin l1 0.0028 0.0157 0.0142
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0073 0.0054
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0194 0.1323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0076 0.0658 0.0644
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0157 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0019 0.0019
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Schistosoma mansoni protein kinase 0.0033 0.0211 0.0196
Schistosoma mansoni glucose transporter 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0118 0.1096 0.1082
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0019 0.0004
Onchocerca volvulus 0.0028 0.0157 0.1111
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0124 0.0109
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0118 0.1096 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.011 0.0095
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0053 0.0418 0.0404
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0115 0.1064 0.1051
Entamoeba histolytica hypothetical protein 0.0024 0.011 0.0714
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1814 0.1802
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0206 0.0191
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0194
Brugia malayi nuclear receptor RXR 0.0036 0.0239 0.0224
Entamoeba histolytica protein kinase, putative 0.0033 0.0211 0.1476
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.1651 0.1638
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0157 0.0142
Schistosoma mansoni protein kinase 0.0033 0.0211 0.0196
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0062 0.0511 0.0497
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0262 0.196
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0142 0.1344 0.1344
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0038 0.0262 0.196
Onchocerca volvulus 0.0076 0.0658 0.516
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0115 0.1064 0.1064
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0157 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Brugia malayi nuclear receptor NHR-88 0.0036 0.0239 0.0224
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0194 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0038 0.0262 0.1857
Onchocerca volvulus 0.0062 0.0511 0.3973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) ACC-1 protein 0.0115 0.1064 0.1064
Plasmodium vivax vivapain-2 0.0028 0.0157 0.0142
Brugia malayi follicle stimulating hormone receptor 0.0194 0.1887 0.1875
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0076 0.0658 0.0644
Trypanosoma brucei glucose transporter 1E 0.0033 0.0206 0.0191
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Schistosoma mansoni isocitrate dehydrogenase 0.0118 0.1096 0.1082
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0206 0.0191
Schistosoma mansoni glucose transport protein 0.0106 0.0964 0.095
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.0964 0.095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0076 0.0658 0.0644
Schistosoma mansoni sugar transporter 0.0015 0.0019 0.0004
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0118 0.1096 0.1096
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.006 0.0045
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.011 0.0843
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0359 0.2748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.006 0.0229
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0043 0.031 0.0295
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.011 0.5
Toxoplasma gondii ck2 beta subunit 0.0038 0.0262 0.0243
Loa Loa (eye worm) hypothetical protein 0.004 0.0284 0.0284
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0194 0.018
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0019 0.0004
Toxoplasma gondii cathepsin CPL 0.0028 0.0157 0.0138
Schistosoma mansoni hypothetical protein 0.0106 0.0964 0.095
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.1036 0.9448
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0211 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0076 0.0658 0.0644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1987 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0211 0.0197
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0206 0.0191
Trypanosoma brucei Casein kinase II 0.0142 0.1344 0.1331
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Brugia malayi major facilitator superfamily protein 0.0015 0.0019 0.0004
Onchocerca volvulus 0.0115 0.1064 0.8444
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus multilocularis casein kinase ii subunit beta 0.0038 0.0262 0.0247
Brugia malayi ecdysteroid receptor 0.0076 0.0658 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Onchocerca volvulus 0.0028 0.0157 0.1111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0076 0.0658 0.0644
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.0359
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0124 0.0109
Echinococcus granulosus calcium dependent protein kinase 0.003 0.018 0.0166
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.011 0.0091
Loa Loa (eye worm) steroid hormone receptor 0.0076 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0239 0.0239
Brugia malayi hypothetical protein 0.0053 0.0418 0.0404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Echinococcus granulosus solute carrier family 22 0.0015 0.0019 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0206 0.0966
Schistosoma mansoni nAChR subunit 0.0115 0.1064 0.1051
Schistosoma mansoni nAChR subunit 0.0053 0.0418 0.0404
Echinococcus multilocularis tumor protein p63 0.0337 0.3369 0.3359
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0019 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0076 0.0658 0.0644
Schistosoma mansoni nAChR subunit 0.0053 0.0418 0.0404
Loa Loa (eye worm) acetylcholine receptor protein 0.0053 0.0418 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) fibroinase 0.0028 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.021 0.2046 0.2046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0211 0.0196
Onchocerca volvulus 0.0115 0.1064 0.8444
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0118 0.1096 1
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0062 0.0511 0.0497
Toxoplasma gondii isocitrate dehydrogenase 0.0974 1 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1064 0.1064
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0211 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0211 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0378 0.0363
Trichomonas vaginalis glucosylceramidase, putative 0.0134 0.1257 0.6299
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0284 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Schistosoma mansoni acetylcholine receptor subunit beta 0.0053 0.0418 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0359 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0076 0.0658 0.0644
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Plasmodium falciparum hexose transporter 0.0106 0.0964 0.095
Trypanosoma brucei glucose transporter 2A 0.0033 0.0206 0.0191
Leishmania major cathepsin L-like protease 0.0028 0.0157 0.0138
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0211 0.0196
Entamoeba histolytica protein kinase, putative 0.0033 0.0211 0.1476
Echinococcus multilocularis glycine receptor subunit beta 0.0115 0.1064 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0062 0.0511 0.0497
Schistosoma mansoni retinoic acid receptor RXR 0.0242 0.2377 0.2366
Leishmania major glucose transporter, lmgt1 0.0033 0.0206 0.0187
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.004 0.0284 0.0269
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0204 0.1987 0.1987
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0118 0.1096 0.5481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0157 0.0718
Trypanosoma brucei glucose transporter, putative 0.0033 0.0206 0.0191
Leishmania major cysteine peptidase A (CPA) 0.0028 0.0157 0.0138
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0211 0.0197
Loa Loa (eye worm) hypothetical protein 0.0062 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0053 0.0418 0.0418
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0019 0.0004
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0206 0.0191
Schistosoma mansoni unc-13 (munc13) 0.0118 0.1096 0.1082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0076 0.0658 0.0658
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0053 0.0418 0.0404
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.018 0.0166
Onchocerca volvulus 0.0115 0.1064 0.8444
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0115 0.1064 0.1051
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.0239 0.0224
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0974 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.0239 0.1775
Loa Loa (eye worm) nuclear receptor NHR-67 0.0036 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Echinococcus granulosus tumor protein p63 0.0337 0.3369 0.3359
Echinococcus multilocularis solute carrier family 22 0.0015 0.0019 0.0004
Brugia malayi mbt repeat family protein 0.0048 0.0359 0.0345
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0115 0.1064 0.1051
Trypanosoma cruzi cruzipain precursor, putative 0.0107 0.0977 0.0964
Onchocerca volvulus Protein ultraspiracle homolog 0.0076 0.0658 0.516
Schistosoma mansoni nuclear receptor 0.0036 0.0239 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.1344 0.6738
Trichomonas vaginalis casein kinase II beta chain, putative 0.0038 0.0262 0.1251
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0115 0.1064 0.1064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0107 0.0977 0.0964
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0019 0.0021
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.011 0.0095
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0115 0.1064 0.1051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0076 0.0658 0.0644
Echinococcus granulosus survival motor neuron protein 1 0.021 0.2046 0.2034
Schistosoma mansoni protein kinase 0.0142 0.1344 0.1331
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0115 0.1064 0.1051
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0115 0.1064 0.1051
Brugia malayi hypothetical protein 0.021 0.2046 0.2034
Brugia malayi Casein kinase II, alpha chain 0.0142 0.1344 0.1331
Brugia malayi hypothetical protein 0.0025 0.0124 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0206 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0157 0.0718
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Leishmania major casein kinase II, putative 0.0142 0.1344 0.1327
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0194
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0053 0.0418 0.0404

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 390 nM Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay ChEMBL. 18800761
EC50 (functional) = 631 nM Agonist activity towards mouse Melanocortin-5 receptor (mMC5R) ChEMBL. 12086493
EC50 (functional) = 631 nM Agonist activity towards mouse Melanocortin-5 receptor (mMC5R) ChEMBL. 12086493
EC50 (functional) = 730 nM Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay ChEMBL. 18800761
EC50 (functional) = 2400 nM Agonist activity to the mouse Melanocortin-4 receptor (mMC4R) ChEMBL. 12086493
EC50 (functional) = 2400 nM Agonist activity to the mouse Melanocortin-4 receptor (mMC4R) ChEMBL. 12086493
EC50 (functional) = 2600 nM Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay ChEMBL. 18800761
EC50 (functional) = 3200 nM Agonist activity to the mouse Melanocortin-1 receptor (mMC1R) ChEMBL. 12086493
EC50 (functional) = 3200 nM Agonist activity to the mouse Melanocortin-1 receptor (mMC1R) ChEMBL. 12086493
EC50 (functional) = 12500 nM Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay ChEMBL. 18800761
EC50 (functional) = 34000 nM Agonist activity to the mouse Melanocortin-3 receptor (mMC3R) ChEMBL. 12086493
EC50 (functional) = 34000 nM Agonist activity to the mouse Melanocortin-3 receptor (mMC3R) ChEMBL. 12086493
FC (functional) = 23 Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide ChEMBL. 18800761
FC (functional) = 99 Agonist activity at mouse MC3R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide ChEMBL. 18800761
FC (functional) = 171 Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide ChEMBL. 18800761
FC (functional) = 223 Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide ChEMBL. 18800761

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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