Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2c (5-HT2c) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5121 | 0.9544 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5357 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.5121 | 0.9544 | 1 |
Onchocerca volvulus | 0.5121 | 0.9544 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5357 | 1 | 1 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.035 | 0.0329 | 0.0329 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0444 | 0.0511 | 0.0535 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0444 | 0.0511 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1801 | 0.3133 | 0.3282 |
Echinococcus granulosus | thymidylate synthase | 0.5121 | 0.9544 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0444 | 0.0511 | 0.0535 |
Brugia malayi | Dihydrofolate reductase | 0.0444 | 0.0511 | 0.0535 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.5121 | 0.9544 | 1 |
Brugia malayi | hypothetical protein | 0.2436 | 0.4359 | 0.4567 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.035 | 0.0329 | 0.0329 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5121 | 0.9544 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0444 | 0.0511 | 0.0535 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2436 | 0.4359 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0444 | 0.0511 | 0.0535 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2436 | 0.4359 | 0.4359 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5357 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.5121 | 0.9544 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.035 | 0.0329 | 0.0329 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.035 | 0.0329 | 0.0329 |
Brugia malayi | dihydrofolate reductase family protein | 0.0444 | 0.0511 | 0.0535 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0444 | 0.0511 | 0.0535 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1801 | 0.3133 | 0.2902 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5357 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.1801 | 0.3133 | 0.2902 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5357 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.5121 | 0.9544 | 1 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.0743 | 0.0778 |
Brugia malayi | thymidylate synthase | 0.5121 | 0.9544 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2436 | 0.4359 | 0.4567 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 28 nM | Displacement of [3H]-mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptor | ChEMBL. | 10956215 |
Ki (binding) | = 28 nM | Displacement of [3H]-mesulergine from A9 cells stably expressing rat 5-hydroxytryptamine 2C receptor | ChEMBL. | 10956215 |
Ki (binding) | = 150 nM | Displacement of [3H]-ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptor | ChEMBL. | 10956215 |
Ki (binding) | = 150 nM | Displacement of [3H]-ketanserin from NIH3T3 cells stably expressing rat 5-hydroxytryptamine 2A receptor | ChEMBL. | 10956215 |
Selectivity (binding) | = 0.2 | Relative affinities for rat 5-HT2C receptors and 5-HT2A receptors | ChEMBL. | 10956215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.