Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0079 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0079 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0079 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0079 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0079 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.6 uM | Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay | ChEMBL. | 23010270 |
IC50 (binding) | = 12.64 uM | Inhibition of human recombinant COX2 expressed in insect cells using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay | ChEMBL. | 23010270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.