Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0351 | 0.0351 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.249 | 0.2826 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3338 | 0.3338 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2225 | 0.2525 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3338 | 0.3787 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2225 | 0.2225 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3338 | 0.3338 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3338 | 0.3787 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0351 | 0.0351 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0351 | 0.0351 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3338 | 0.3338 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0351 | 0.0351 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2225 | 0.2225 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0351 | 0.0398 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.15 | 0.1702 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3338 | 0.3338 |
Echinococcus multilocularis | geminin | 0.0165 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2225 | 0.2225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2225 | 0.2225 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3338 | 0.3787 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.249 | 0.2826 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2225 | 0.2225 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0351 | 0.0398 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0351 | 0.0398 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0351 | 0.0351 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.249 | 0.2826 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3338 | 0.3787 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0351 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.15 | 0.1702 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0351 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.8814 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0351 | 0.0351 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.8814 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.8814 | 0.8814 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.8814 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.8814 | 0.8814 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.15 | 0.15 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.8814 | 0.8814 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3338 | 0.3338 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3338 | 0.3787 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.249 | 0.2826 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3338 | 0.3338 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2225 | 0.2225 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3338 | 0.3338 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0351 | 0.0351 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0351 | 0.0351 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0351 | 0.0351 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2225 | 0.2525 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3338 | 0.3787 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2225 | 0.2225 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 28 nM | Antagonist activity at CCR3 receptor | ChEMBL. | 23046963 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.