Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0106 | 0.0907 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0341 | 0.6823 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1514 | 0.0667 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Onchocerca volvulus | 0.013 | 0.1514 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0277 | 0.5211 | 0.7638 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0468 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0468 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0468 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0277 | 0.5211 | 0.4733 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0468 | 1 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0267 | 0.4968 | 0.407 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0267 | 0.4968 | 0.407 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0106 | 0.0907 | 0.133 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0277 | 0.5211 | 0.7276 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1514 | 0.0667 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0341 | 0.6823 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0468 | 1 | 1 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0172 | 0.2563 | 0.2799 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0277 | 0.5211 | 0.7276 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1514 | 0.0667 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0277 | 0.5211 | 0.7276 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0106 | 0.0907 | 0.133 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0277 | 0.5211 | 0.4733 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0277 | 0.5211 | 0.4733 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.62 | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 6.05 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 0.9 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 0.9 uM | Inhibition of rat liver dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 0.9 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 2.4 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 2.4 uM | Inhibition of Toxoplasma gondii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 2.4 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 14 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
IC50 (binding) | = 14 uM | Inhibition of Pneumocystis carinii dihydrofolate reductase | ChEMBL. | 9301665 |
Inhibition (binding) | = 11 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Inhibition (binding) | = 11 % | Percentage inhibition against Pneumocystis carinii Dihydrofolate reductase. | ChEMBL. | 9301665 |
Selectivity ratio (binding) | = 0.38 | Relative binding affinity to rat liver and Toxoplasma gondii DHFR. | ChEMBL. | 9301665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.