Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Janus kinase 1 | Starlite/ChEMBL | References |
Homo sapiens | Janus kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0218 | 0.4044 | 0.7391 |
Schistosoma mansoni | thyroid hormone receptor | 0.0218 | 0.4044 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0218 | 0.4044 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0218 | 0.4044 | 0.7391 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | nuclear receptor NHR-88 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 0.7391 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0218 | 0.4044 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0218 | 0.4044 | 0.7391 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0218 | 0.4044 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | FTZ F1 alpha | 0.0218 | 0.4044 | 0.7391 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | nuclear hormone receptor | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 0.7391 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0218 | 0.4044 | 0.4044 |
Onchocerca volvulus | 0.0218 | 0.4044 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | ecdysteroid receptor | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0218 | 0.4044 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0254 | 0.5471 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0218 | 0.4044 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0218 | 0.4044 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0218 | 0.4044 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0218 | 0.4044 | 0.7391 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0218 | 0.4044 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0218 | 0.4044 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0218 | 0.4044 | 0.7391 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0218 | 0.4044 | 0.4044 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0218 | 0.4044 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0218 | 0.4044 | 0.4044 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0218 | 0.4044 | 0.7391 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4044 | 0.4044 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0218 | 0.4044 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0218 | 0.4044 | 0.4044 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0218 | 0.4044 | 0.4044 |
Schistosoma mansoni | coup transcription factor | 0.0218 | 0.4044 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0218 | 0.4044 | 0.4044 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0218 | 0.4044 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0218 | 0.4044 | 0.4044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 270 nM | Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins prior to IL6-induction measured after 30 to 45 mins | ChEMBL. | 22698084 |
EC50 (binding) | = 2200 nM | Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins prior to EPO-induction measured after 30 to 45 mins | ChEMBL. | 22698084 |
Ki (binding) | = 5.8 nM | Inhibition of JAK1 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins | ChEMBL. | 22698084 |
Ki (binding) | = 24 nM | Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 mins | ChEMBL. | 22698084 |
T1/2 (ADMET) | > 8 hr | Half life in human hepatocytes at 1 uM by LC/MS/MS analysis | ChEMBL. | 22698084 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.