Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 5 | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0043 | 0.0096 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.3893 | 0.3893 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0043 | 0.0096 | 0.0132 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0309 | 0.3491 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0602 | 0.724 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0602 | 0.724 | 1 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1158 | 0.1158 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0043 | 0.0096 | 0.0132 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0181 | 0.0181 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0043 | 0.0096 | 0.017 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0043 | 0.0096 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1158 | 0.1158 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0126 | 0.1158 | 0.1158 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0309 | 0.3491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0181 | 0.0181 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0309 | 0.3491 | 0.3491 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0043 | 0.0096 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0475 | 0.5623 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0309 | 0.3491 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0181 | 0.0181 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0043 | 0.0096 | 0.017 |
Brugia malayi | Kelch motif family protein | 0.0126 | 0.1158 | 0.1158 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0043 | 0.0096 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0043 | 0.0096 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.034 | 0.3893 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0817 | 1 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0309 | 0.3491 | 1 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0043 | 0.0096 | 0.0132 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0309 | 0.3491 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.034 | 0.3893 | 0.3893 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0181 | 0.0181 |
Plasmodium vivax | polyprenol reductase, putative | 0.0043 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0096 | 0.0246 | |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.3491 | 0.3491 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0043 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0096 | 0.0096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.2 nM | Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysis | ChEMBL. | 23140358 |
IC50 (binding) | = 114 nM | Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta5 receptor after 3 hrs by microplate reader analysis | ChEMBL. | 23140358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.