Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | snurportin 1 | 0.0343 | 0.0546 | 0.084 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0976 | 0.1622 | 0.2494 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0076 | 0.0091 | 0.014 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.123 | 0.2053 | 0.3157 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0007 | 0.0513 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0003 | 0.0005 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0017 | 0.0027 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2068 | 0.3477 | 0.5346 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0052 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0048 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0052 | 0.0021 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0076 | 0.0091 | 0.014 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.001 | 0.0015 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0057 | 0.0088 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0343 | 0.0546 | 0.084 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0031 | 0.0048 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0017 | 0.2921 |
Loa Loa (eye worm) | hypothetical protein | 0.0976 | 0.1622 | 0.2494 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0052 | 1 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0052 | 0.0081 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0976 | 0.1622 | 0.2494 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5672 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0076 | 0.0117 |
Echinococcus multilocularis | insulin receptor | 0.123 | 0.2053 | 0.3157 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0052 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 0.0376 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0017 | 0.0014 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0003 | 0.0005 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.012 | 0.0167 | 0.0137 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0031 | 0.3513 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0027 | 0.0042 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0031 | 0.0048 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 0.0376 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0767 | 0.1266 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0134 | 0.019 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0074 | 0.0114 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.5906 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0017 | 0.2921 |
Toxoplasma gondii | hypothetical protein | 0.0166 | 0.0244 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0031 | 0.3513 |
Schistosoma mansoni | tyrosine kinase | 0.123 | 0.2053 | 0.3157 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0052 | 0.0049 |
Plasmodium vivax | amine transporter, putative | 0.0166 | 0.0244 | 0.0241 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0134 | 0.019 | 0.016 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0767 | 0.1266 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0905 | 0.15 | 0.2306 |
Schistosoma mansoni | tyrosine kinase | 0.2046 | 0.344 | 0.5289 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0166 | 0.0244 | 0.0376 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0031 | 0.3513 |
Schistosoma mansoni | tyrosine kinase | 0.2068 | 0.3477 | 0.5346 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Brugia malayi | beta-lactamase | 0.004 | 0.0031 | 0.0048 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5906 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0057 | 0.0088 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0166 | 0.0244 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0017 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0976 | 0.1622 | 0.2494 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0052 | 0.0081 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0052 | 0.0081 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0767 | 0.1266 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0134 | 0.019 | 0.016 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0031 | 0.0048 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0052 | 0.0081 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0134 | 0.019 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0166 | 0.0244 | 0.0376 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0031 | 0.3513 |
Plasmodium falciparum | transporter, putative | 0.0166 | 0.0244 | 0.0241 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.012 | 0.0167 | 0.0137 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0166 | 0.0244 | 0.0376 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.0105 | 0.0161 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0017 | 0.0027 |
Schistosoma mansoni | ran | 0.0024 | 0.0003 | 0.0005 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0007 | 0.0829 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0031 | 0.0048 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0031 | 0.0048 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0017 | 0.0014 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0976 | 0.1622 | 0.2494 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0003 | 0.0005 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0057 | 0.0088 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.3849 | 0.6504 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0031 | 0.3513 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0083 | 0.0103 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0031 | 0.1161 |
Loa Loa (eye worm) | hypothetical protein | 0.0976 | 0.1622 | 0.2494 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0166 | 0.0244 | 0.0376 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.0118 | 0.0182 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0052 | 0.0081 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0052 | 0.2047 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5672 |
Mycobacterium tuberculosis | Probable reductase | 0.012 | 0.0167 | 0.0137 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0166 | 0.0244 | 0.0376 |
Brugia malayi | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0007 | 0.0032 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0166 | 0.0244 | 0.0376 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0052 | 0.0081 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0767 | 0.1266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0031 | 0.3513 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0083 | 0.0103 | 0.0158 |
Schistosoma mansoni | tyrosine kinase | 0.2046 | 0.344 | 0.5289 |
Echinococcus multilocularis | 0.1191 | 0.1988 | 0.3056 | |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0027 | 0.0042 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 0.0376 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0166 | 0.0244 | 0.0376 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0767 | 0.1266 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5672 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0007 | 0.0829 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0048 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.123 | 0.2053 | 0.3157 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0976 | 0.1622 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0976 | 0.1622 | 0.2494 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0031 | 0.5672 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.004 | 0.0062 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0031 | 0.0048 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.0244 | 0.0376 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0057 | 0.0088 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2068 | 0.3477 | 0.5346 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0048 |
Schistosoma mansoni | ran | 0.0024 | 0.0003 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0343 | 0.0546 | 0.084 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0031 | 0.0048 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0017 | 0.0027 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0002 | 0.0003 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.5906 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0976 | 0.1622 | 0.2494 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0076 | 0.0091 | 0.014 |
Echinococcus granulosus | snurportin 1 | 0.0343 | 0.0546 | 0.084 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 0.0376 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0976 | 0.1622 | 0.2494 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.0399 | 0.0369 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0031 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0044 | 0.0067 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.2068 | 0.3477 | 0.5346 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0071 | 0.0083 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0166 | 0.0244 | 0.0376 |
Schistosoma mansoni | tyrosine kinase | 0.2068 | 0.3477 | 0.5346 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0071 | 0.0083 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0097 | 0.0149 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.3849 | 0.6504 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.5906 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.0035 | 0.0054 |
Schistosoma mansoni | tyrosine kinase | 0.123 | 0.2053 | 0.3157 |
Onchocerca volvulus | 0.0166 | 0.0244 | 0.1341 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.3849 | 0.6504 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0976 | 0.1622 | 0.2494 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0166 | 0.0244 | 0.0376 |
Onchocerca volvulus | 0.0166 | 0.0244 | 0.1341 | |
Brugia malayi | Protein kinase domain containing protein | 0.123 | 0.2053 | 0.3157 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0166 | 0.0244 | 0.0376 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.012 | 0.0167 | 0.0137 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0052 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0031 | 0.0048 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0076 | 0.0091 | 0.014 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.0083 | 0.0127 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.123 | 0.2053 | 0.3157 |
Onchocerca volvulus | 0.0976 | 0.1622 | 1 | |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0166 | 0.0244 | 0.0376 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0006 | 0.0008 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0031 | 0.0048 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0052 | 0.0049 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0031 | 0.0048 |
Echinococcus granulosus | insulin receptor | 0.123 | 0.2053 | 0.3157 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0003 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0976 | 0.1622 | 0.2494 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0166 | 0.0244 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0006 | 0.0008 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0017 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0048 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0003 | 0.0005 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.012 | 0.0167 | 0.8565 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.012 | 0.0167 | 0.0137 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0166 | 0.0244 | 0.0376 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0166 | 0.0244 | 0.0376 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0007 | 0.0513 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0076 | 0.0117 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0052 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0048 |
Schistosoma mansoni | tyrosine kinase | 0.2046 | 0.344 | 0.5289 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.012 | 0.0167 | 0.0137 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.3849 | 0.6504 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.5906 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.5906 | 1 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.5906 | 1 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0007 | 0.0513 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0017 | 0.0598 |
Plasmodium falciparum | amino acid transporter, putative | 0.0166 | 0.0244 | 0.0241 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0031 | 0.0048 |
Toxoplasma gondii | hypothetical protein | 0.0166 | 0.0244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0031 | 0.0048 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0166 | 0.0244 | 0.0376 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0166 | 0.0244 | 0.0376 |
Onchocerca volvulus | 0.0166 | 0.0244 | 0.1341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0027 | 0.0042 |
Plasmodium vivax | hypothetical protein, conserved | 0.0166 | 0.0244 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0036 | 0.0055 |
Schistosoma mansoni | tyrosine kinase | 0.3849 | 0.6504 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Candida albicans | ChEMBL23 | 22989532 | |
Homo sapiens | ChEMBL23 | 22989532 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.