Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.6554 | 0.6554 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0108 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.5112 | 0.4986 |
Schistosoma mansoni | transient receptor potential channel | 0.0108 | 1 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0104 | 0.9577 | 0.9566 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.2002 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.288 | 0.288 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.025 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1759 | 0.1759 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.57 | 0.559 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.558 | 0.558 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.57 | 0.559 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.16 | 0.16 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.3823 | 0.4979 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.5112 | 0.4986 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0071 | 0.57 | 0.559 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.004 | 0.2024 | 0.1819 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.3823 | 0.4979 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0104 | 0.9577 | 0.9566 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5277 | 0.5277 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.2311 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.2002 | 0.1797 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1759 | 0.1759 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0071 | 0.57 | 0.559 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.57 | 0.57 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.263 | 0.263 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.7113 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.3823 | 0.3823 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1759 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2024 | 0.2024 |
Brugia malayi | Transient-receptor-potential like protein | 0.004 | 0.2024 | 0.2234 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0108 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0071 | 0.57 | 0.57 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2321 | 0.2321 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.004 | 0.2024 | 0.1819 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3823 | 0.3823 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 31 % | Analgesic activity in mouse assessed as inhibition of acetic-acid induced writhing at 10 mg/kg administered 15 mins prior to acetic acid-challenge measured for 15 mins relative to vehicle-treated control | ChEMBL. | 23159805 |
MIC (functional) | = 250 ug ml-1 | Antibacterial activity against Escherichia coli MTCC 4351 after 24 hrs by tube dilution method | ChEMBL. | 23159805 |
MIC (functional) | = 250 ug ml-1 | Antifungal activity against Candida albicans MTCC 183 after 48 hrs by tube dilution method | ChEMBL. | 23159805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.