Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | pteridine reductase 1 | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | pteridine reductase 1 | 288 aa | 281 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2946 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0.8654 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0208 | 0.8654 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0208 | 0.8654 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2946 | 0.2987 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.2946 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0208 | 0.8654 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2946 | 0.2946 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0.8654 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2946 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0.8654 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0208 | 0.8654 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0235 | 0.9862 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0.8654 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2946 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0208 | 0.8654 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0208 | 0.8654 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 47.2 % | Inhibition of pteridine reductase in Leishmania major promastigotes assessed as increase in pyrimethamine-induced growth inhibition by measuring parasite growth at 50 ug/mL | ChEMBL. | 22946585 |
Activity (functional) | = 88.5 % | Antiparasitic activity against Leishmania mexicana promastigotes assessed as parasite growth at 50 ug/mL | ChEMBL. | 22946585 |
Activity (functional) | = 121.2 % | Antiparasitic activity against Leishmania major promastigotes assessed as parasite growth at 50 ug/mL | ChEMBL. | 22946585 |
ED50 (ADMET) | = 51 ug ml-1 | Toxicity against human MRC5 cells assessed as growth inhibition | ChEMBL. | 22946585 |
Inhibition (binding) | Inhibition of human TS at 15 uM by spectrophotometric analysis | ChEMBL. | 22946585 | |
Ki (binding) | = 390 nM | Inhibition of Leishmania major PTR1 by spectrophotometric assay | ChEMBL. | 22946585 |
Ki (binding) | = 15430 nM | Inhibition of human DHFR by spectrophotometric analysis | ChEMBL. | 22946585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.