Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.9701 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.9701 | 0.9633 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.9701 | 0.9633 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1847 | 0.1904 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.1847 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1847 | 0.1904 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.1847 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.1847 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1847 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.9701 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.1847 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.1847 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.5597 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.5597 | 0.4775 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.1847 | 0.1904 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.9701 | 0.9633 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.9701 | 0.9633 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.5597 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.9701 | 0.9633 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.1847 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1847 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.1847 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.1847 | 0.1904 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.9701 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.168 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate Alamar blue assay | ChEMBL. | 22931472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.