Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Leishmania major | DNA topoisomerase type IB small subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroglian | 0.0107473 | 0.114343 | 0.278948 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0669192 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0448864 | 0.65261 | 0.5 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0669192 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0107473 | 0.114343 | 0.881325 |
Schistosoma mansoni | hypothetical protein | 0.0229689 | 0.30704 | 1 |
Echinococcus multilocularis | neuroglian | 0.0107473 | 0.114343 | 0.278948 |
Echinococcus multilocularis | Immunoglobulin | 0.0107473 | 0.114343 | 0.278948 |
Chlamydia trachomatis | 3-hydroxyacyl-ACP dehydratase | 0.0362368 | 0.516233 | 0.78494 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0448864 | 0.65261 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.00466703 | 0.0184761 | 0.028311 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0448864 | 0.65261 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0113636 | 0.124061 | 0.404054 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0113636 | 0.124061 | 0.307225 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0107473 | 0.114343 | 0.278948 |
Plasmodium falciparum | beta-hydroxyacyl-ACP dehydratase | 0.0362368 | 0.516233 | 0.791028 |
Echinococcus granulosus | kinesin family 1 | 0.0264641 | 0.362148 | 1 |
Echinococcus granulosus | twitchin | 0.0107473 | 0.114343 | 0.278948 |
Echinococcus granulosus | roundabout 2 | 0.0107473 | 0.114343 | 0.278948 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0117238 | 0.12974 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0113636 | 0.124061 | 0.956229 |
Loa Loa (eye worm) | oxidoreductase | 0.00466703 | 0.0184761 | 0.142409 |
Plasmodium vivax | topoisomerase I, putative | 0.0113636 | 0.124061 | 0.190099 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.00466703 | 0.0184761 | 0.142409 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0669192 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0113636 | 0.124061 | 0.190099 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0448864 | 0.65261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0107473 | 0.114343 | 0.372404 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0117238 | 0.12974 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0113636 | 0.124061 | 0.956229 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0448864 | 0.65261 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0264641 | 0.362148 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.00466703 | 0.0184761 | 0.142409 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0448864 | 0.65261 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0107473 | 0.114343 | 0.372404 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0448864 | 0.65261 | 1 |
Wolbachia endosymbiont of Brugia malayi | (3R)-hydroxymyristoyl-ACP dehydratase | 0.0362368 | 0.516233 | 0.78494 |
Schistosoma mansoni | nephrin | 0.0107473 | 0.114343 | 0.372404 |
Giardia lamblia | Kinesin-5 | 0.0034952 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0448864 | 0.65261 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Echinococcus multilocularis | Immunoglobulin | 0.0107473 | 0.114343 | 0.278948 |
Echinococcus granulosus | Immunoglobulin | 0.0107473 | 0.114343 | 0.278948 |
Onchocerca volvulus | 0.00466703 | 0.0184761 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.00466703 | 0.0184761 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0107473 | 0.114343 | 0.278948 |
Plasmodium vivax | beta-hydroxyacyl-ACP dehydratase precursor, putative | 0.0362368 | 0.516233 | 0.791028 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0113636 | 0.124061 | 0.307225 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.00466703 | 0.0184761 | 0.028311 |
Echinococcus granulosus | defective proboscis extension response | 0.0107473 | 0.114343 | 0.278948 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0107473 | 0.114343 | 0.372404 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0448864 | 0.65261 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0107473 | 0.114343 | 0.881325 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.00466703 | 0.0184761 | 0.0601748 |
Plasmodium falciparum | topoisomerase I | 0.0113636 | 0.124061 | 0.190099 |
Toxoplasma gondii | beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) | 0.0362368 | 0.516233 | 0.791028 |
Loa Loa (eye worm) | hypothetical protein | 0.0107473 | 0.114343 | 0.881325 |
Schistosoma mansoni | cell adhesion molecule | 0.0107473 | 0.114343 | 0.372404 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.00466703 | 0.0184761 | 0.028311 |
Echinococcus multilocularis | roundabout 2 | 0.0107473 | 0.114343 | 0.278948 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.98 % | Induction of apoptosis in Leishmania infantum promastigotes at 400 uM after 24 hrs by AnnexinV-FITC/propidium iodide based FACS flow cytometry | ChEMBL. | 22932312 |
EC50 (binding) | = 5.3 uM | Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA after 30 mins by ethidium bromide staining based agarose gel electrophoresis | ChEMBL. | 22932312 |
IC50 (functional) | = 0.34 ug ml-1 | Antimalarial activity against liver stage of Plasmodium berghei infected in human Huh7 cells assessed as reduction in parasite load treated after 2 hrs of infection for 46 hrs by luciferase assay | ChEMBL. | 25103602 |
IC50 (functional) | = 6 ug ml-1 | Antimalarial activity against blood stage of multidrug-resistant Plasmodium falciparum K1 after 72 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 25103602 |
IC50 (functional) | = 11 uM | Antiprotozoal activity against Leishmania donovani axenic amastigotes | ChEMBL. | 22932312 |
IC50 (functional) | = 48.1 uM | Antiprotozoal activity against intracellular Trypanosoma cruzi amastigotes in rat L6 cells | ChEMBL. | 22932312 |
IC50 (functional) | = 64.5 uM | Antiprotozoal activity against Trypanosoma brucei rhodesiense bloodstream forms | ChEMBL. | 22932312 |
Inhibition (functional) | Antimalarial activity against liver stage of GFP-expressing Plasmodium berghei infected in human Huh7 cells assessed as reduction in parasite load treated after 2 hrs of infection for 46 hrs by confocal microscopy | ChEMBL. | 25103602 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 25103602 | ||
Leishmania donovani | ChEMBL23 | 22932312 | |
Plasmodium berghei | ChEMBL23 | 25103602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.