Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | Starlite/ChEMBL | References |
Homo sapiens | integrin, beta 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.0043 | 0.0096 | 0.0132 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0309 | 0.3491 | 1 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0309 | 0.3491 | 0.3491 |
Mycobacterium ulcerans | hypothetical protein | 0.0309 | 0.3491 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0043 | 0.0096 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0309 | 0.3491 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.034 | 0.3893 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0475 | 0.5623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0096 | 0.0096 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0602 | 0.724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1158 | 0.1158 |
Brugia malayi | ecdysteroid receptor | 0.034 | 0.3893 | 0.3893 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.0043 | 0.0096 | 0.0132 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0181 | 0.0181 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1158 | 0.1158 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0181 | 0.0181 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0309 | 0.3491 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0043 | 0.0096 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0602 | 0.724 | 1 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0043 | 0.0096 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0817 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.3491 | 0.3491 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0043 | 0.0096 | 0.017 |
Brugia malayi | Kelch motif family protein | 0.0126 | 0.1158 | 0.1158 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.0043 | 0.0096 | 0.017 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0043 | 0.0096 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0096 | 0.0246 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0126 | 0.1158 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.3893 | 0.3893 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0309 | 0.3491 | 0.5 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.0043 | 0.0096 | 0.0096 |
Plasmodium vivax | polyprenol reductase, putative | 0.0043 | 0.0096 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0309 | 0.3491 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0096 | 0.0096 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.0043 | 0.0096 | 0.0132 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.0043 | 0.0096 | 0.0132 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.6 nM | Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta3 receptor after 3 hrs by microplate reader analysis | ChEMBL. | 23140358 |
IC50 (binding) | = 216 nM | Competitive inhibition of biotinylated vitronectin to integrin alphaVbeta5 receptor after 3 hrs by microplate reader analysis | ChEMBL. | 23140358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.