Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0146 | 0.5576 | 0.5576 |
Onchocerca volvulus | 0.0146 | 0.5576 | 0.5 | |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 1 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.5576 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.5576 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 1 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.5576 | 0.5 | |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.5576 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.11 uM | Inhibition of human DHODH expressed in Escherichia coli BL21(DE3) using L-dihydroorotate as substrate after 10 mins by DCIP dye reduction assay | ChEMBL. | 22984987 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human Jurkat cells after 4 days by MTT assay | ChEMBL. | 22984987 |
Inhibition (binding) | < 20 % | Inhibition of Plasmodium falciparum DHODH expressed in Escherichia coli BL21 (DE3) using L-dihydroorotate as substrate at 10 uM after 10 mins by DCIP dye reduction assay | ChEMBL. | 22984987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.