Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.027 | 0.3454 | 1 |
Onchocerca volvulus | 0.027 | 0.3454 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Trypanosoma cruzi | aldo-keto reductase | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Echinococcus granulosus | aldehyde reductase | 0.0192 | 0.2424 | 0.7018 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.027 | 0.3454 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0113 | 0.1386 | 0.4012 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | hypothetical protein | 0.027 | 0.3454 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0192 | 0.2424 | 0.5922 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 0.3454 | 0.3454 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.027 | 0.3454 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0078 | 0.0928 | 0.0928 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 0.3454 | 1 |
Onchocerca volvulus | 0.027 | 0.3454 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Onchocerca volvulus | 0.027 | 0.3454 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Toxoplasma gondii | aldose reductase, putative | 0.027 | 0.3454 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0078 | 0.0928 | 0.5 |
Giardia lamblia | Aldose reductase | 0.027 | 0.3454 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 0.3454 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0192 | 0.2424 | 0.2424 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0078 | 0.0928 | 0.2688 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Echinococcus granulosus | aldo keto reductase | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Schistosoma mansoni | pol-related | 0.027 | 0.3454 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 0.3454 | 0.3454 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.027 | 0.3454 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.027 | 0.3454 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0078 | 0.0928 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.027 | 0.3454 | 1 |
Onchocerca volvulus | 0.027 | 0.3454 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0078 | 0.0928 | 0.2688 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0078 | 0.0928 | 0.2688 |
Leishmania major | aldo-keto reductase-like protein | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.027 | 0.3454 | 0.3454 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.027 | 0.3454 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0113 | 0.1386 | 0.4012 |
Brugia malayi | NADH-dependent xylose reductase | 0.0078 | 0.0928 | 0.2688 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.027 | 0.3454 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0078 | 0.0928 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.027 | 0.3454 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 0.3454 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.027 | 0.3454 | 1 |
Onchocerca volvulus | 0.027 | 0.3454 | 1 | |
Entamoeba histolytica | aldose reductase, putative | 0.027 | 0.3454 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0078 | 0.0928 | 0.5 |
Schistosoma mansoni | potassium channel beta | 0.0078 | 0.0928 | 0.2688 |
Brugia malayi | MH2 domain containing protein | 0.0113 | 0.1386 | 0.4012 |
Giardia lamblia | Aldose reductase | 0.027 | 0.3454 | 0.5 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0078 | 0.0928 | 0.2688 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.027 | 0.3454 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 0.3454 | 0.3454 |
Echinococcus multilocularis | aldo keto reductase | 0.027 | 0.3454 | 0.3454 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Onchocerca volvulus | 0.027 | 0.3454 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.027 | 0.3454 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.027 | 0.3454 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.027 | 0.3454 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis 2745/09 | ChEMBL. | 22916795 |
Stability (ADMET) | = 90 % | Metabolic stability in human plasma | ChEMBL. | 22916795 |
Stability (ADMET) | = 104 % | Metabolic stability in mouse plasma | ChEMBL. | 22916795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.