Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.794 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.794 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0036 | 0.794 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.794 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.794 | 0.7285 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0036 | 0.794 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.794 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0036 | 0.794 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0036 | 0.794 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0036 | 0.794 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.794 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.0036 | 0.794 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0036 | 0.794 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.794 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.794 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.794 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0036 | 0.794 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0036 | 0.794 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.794 | 0.7285 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0036 | 0.794 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.794 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.794 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.794 | 0.5 |
Leishmania major | pyruvate kinase | 0.0036 | 0.794 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0036 | 0.794 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 12 uM | Activation of PDK1 assessed as half maximal activation using KTFCGTPEYLAPEVRR as substrate and [gamma32P]-ATP/Mg2+ by phosphor imaging analysis | ChEMBL. | 23106316 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.